Seroatlas · Human Serome Atlas

DSTN

Destrin

Also known as: ACTDP, ADF, DEST_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60981
Gene: DSTN
Ensembl: ENSG00000125868
Chromosome: 20
Canonical length: 165 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>P60981|DSTN
     1  MASGVQVADE VCRIFYDMKV RKCSTPEEIK KRKKAVIFCL SADKKCIIVE EGKEILVGDV
    61  GVTITDPFKH FVGMLPEKDC RYALYDASFE TKESRKEELM FFLWAPELAP LKSKMIYASS
   121  KDAIKKKFQG IKHECQANGP EDLNRACIAE KLGGSLIVAF EGCPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DSTN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 2,616 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 2,616 nTPM
colon: 1,069 nTPM
seminal vesicle: 714 nTPM
urinary bladder: 661 nTPM
smooth muscle: 649 nTPM
endometrium: 570 nTPM

Single-cell type

vascular smooth muscle cells: 4,533 nCPM
alveolar cells type 1: 3,627 nCPM
smooth muscle cells: 3,355 nCPM
esophageal apical cells: 3,181 nCPM
transitional alveolar cells: 1,730 nCPM
extravillous trophoblasts: 1,657 nCPM

Immune cell

eosinophil: 60 nTPM
memory CD4 T-cell: 57 nTPM
gdT-cell: 56 nTPM
memory CD8 T-cell: 52 nTPM
plasmacytoid DC: 51 nTPM
NK-cell: 49 nTPM

Brain region

white matter: 153 nTPM
hypothalamus: 144 nTPM
pons: 137 nTPM
midbrain: 129 nTPM
cerebral cortex: 127 nTPM
hippocampal formation: 125 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.55
gnomAD missense Z: 1.23
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin filament binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DSTN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DSTN as an antibody target. Whether an autoantibody or antibody against DSTN could matter depends on whether native DSTN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DSTN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DSTN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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