Seroatlas · Human Serome Atlas

TWF2

Twinfilin-2

Also known as: A6r, A6RP, PTK9L, TWF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IBS0
Gene: TWF2
Ensembl: ENSG00000247596
Chromosome: 3
Canonical length: 349 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>Q6IBS0|TWF2
     1  MAHQTGIHAT EELKEFFAKA RAGSVRLIKV VIEDEQLVLG ASQEPVGRWD QDYDRAVLPL
    61  LDAQQPCYLL YRLDSQNAQG FEWLFLAWSP DNSPVRLKML YAATRATVKK EFGGGHIKDE
   121  LFGTVKDDLS FAGYQKHLSS CAAPAPLTSA ERELQQIRIN EVKTEISVES KHQTLQGLAF
   181  PLQPEAQRAL QQLKQKMVNY IQMKLDLERE TIELVHTEPT DVAQLPSRVP RDAARYHFFL
   241  YKHTHEGDPL ESVVFIYSMP GYKCSIKERM LYSSCKSRLL DSVEQDFHLE IAKKIEIGDG
   301  AELTAEFLYD EVHPKQHAFK QAFAKPKGPG GKRGHKRLIR GPGENGDDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TWF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

spleen: 48 nTPM
adipose tissue: 45 nTPM
esophagus: 41 nTPM
blood vessel: 37 nTPM
breast: 36 nTPM
cervix: 34 nTPM

Single-cell type

early spermatids: 63 nCPM
late spermatids: 38 nCPM
epicardial cells: 18 nCPM
neutrophils: 16 nCPM
cardiomyocytes: 15 nCPM
adipocytes: 12 nCPM

Immune cell

neutrophil: 243 nTPM
non-classical monocyte: 183 nTPM
intermediate monocyte: 169 nTPM
classical monocyte: 168 nTPM
myeloid DC: 160 nTPM
plasmacytoid DC: 151 nTPM

Brain region

white matter: 29 nTPM
hippocampal formation: 27 nTPM
cerebral cortex: 25 nTPM
basal ganglia: 25 nTPM
pons: 25 nTPM
spinal cord: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TWF2.

Disease | ImmuneIEDB

Conditions an epitope on TWF2 was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: 1.08
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TWF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TWF2 as an antibody target. Whether an autoantibody or antibody against TWF2 could matter depends on whether native TWF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TWF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TWF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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