Seroatlas · Human Serome Atlas

CAPG

Macrophage-capping protein

Also known as: AFCP, CAPG_HUMAN, MCP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P40121
Gene
CAPG
Ensembl
ENSG00000042493
Chromosome
2
Canonical length
348 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitotic chromosome

OverviewNCBI Gene

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>P40121|CAPG
     1  MYTAIPQSGS PFPGSVQDPG LHVWRVEKLK PVPVAQENQG VFFSGDSYLV LHNGPEEVSH
    61  LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG NESDLFMSYF PRGLKYQEGG
   121  VESAFHKTST GAPAAIKKLY QVKGKKNIRA TERALNWDSF NTGDCFILDL GQNIFAWCGG
   181  KSNILERNKA RDLALAIRDS ERQGKAQVEI VTDGEEPAEM IQVLGPKPAL KEGNPEEDLT
   241  ADKANAQAAA LYKVSDATGQ MNLTKVADSS PFALELLISD DCFVLDNGLC GKIYIWKGRK
   301  ANEKERQAAL QVAEGFISRM QYAPNTQVEI LPQGHESPIF KQFFKDWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
228 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 228 nTPM
  • skin: 172 nTPM
  • kidney: 160 nTPM
  • bone marrow: 151 nTPM
  • lung: 150 nTPM
  • parathyroid gland: 143 nTPM

Single-cell type

  • esophageal apical cells: 719 nCPM
  • esophageal suprabasal cells: 618 nCPM
  • mast cells: 521 nCPM
  • extravillous trophoblasts: 509 nCPM
  • hofbauer cells: 508 nCPM
  • esophageal basal cells: 355 nCPM

Immune cell

  • myeloid DC: 1,365 nTPM
  • basophil: 1,142 nTPM
  • classical monocyte: 1,141 nTPM
  • total PBMC: 977 nTPM
  • plasmacytoid DC: 962 nTPM
  • eosinophil: 715 nTPM

Brain region

  • white matter: 105 nTPM
  • thalamus: 80 nTPM
  • medulla oblongata: 62 nTPM
  • spinal cord: 58 nTPM
  • pons: 47 nTPM
  • hypothalamus: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.46
gnomAD pLI
0
gnomAD missense Z
0.37
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAPG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPG as an antibody target. Whether an autoantibody or antibody against CAPG could matter depends on whether native CAPG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAPG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAPG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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