Seroatlas · Human Serome Atlas

VILL

Villin-like protein

Also known as: VILL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15195
Gene: VILL
Ensembl: ENSG00000136059
Chromosome: 3
Canonical length: 856 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a headpiece domain. It may play a role in actin-bundling. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

856 residues, UniProt reviewed canonical sequence.

>O15195|VILL
     1  MDISKGLPGM QGGLHIWISE NRKMVPVPEG AYGNFFEEHC YVILHVPQSP KATQGASSDL
    61  HYWVGKQAGA EAQGAAEAFQ QRLQDELGGQ TVLHREAQGH ESDCFCSYFR PGIIYRKGGL
   121  ASDLKHVETN LFNIQRLLHI KGRKHVSATE VELSWNSFNK GDIFLLDLGK MMIQWNGPKT
   181  SISEKARGLA LTYSLRDRER GGGRAQIGVV DDEAKAPDLM QIMEAVLGRR VGSLRAATPS
   241  KDINQLQKAN VRLYHVYEKG KDLVVLELAT PPLTQDLLQE EDFYILDQGG FKIYVWQGRM
   301  SSLQERKAAF SRAVGFIQAK GYPTYTNVEV VNDGAESAAF KQLFRTWSEK RRRNQKLGGR
   361  DKSIHVKLDV GKLHTQPKLA AQLRMVDDGS GKVEVWCIQD LHRQPVDPKR HGQLCAGNCY
   421  LVLYTYQRLG RVQYILYLWQ GHQATADEIE ALNSNAEELD VMYGGVLVQE HVTMGSEPPH
   481  FLAIFQGQLV IFQERAGHHG KGQSASTTRL FQVQGTDSHN TRTMEVPARA SSLNSSDIFL
   541  LVTASVCYLW FGKGCNGDQR EMARVVVTVI SRKNEETVLE GQEPPHFWEA LGGRAPYPSN
   601  KRLPEEVPSF QPRLFECSSH MGCLVLAEVG FFSQEDLDKY DIMLLDTWQE IFLWLGEAAS
   661  EWKEAVAWGQ EYLKTHPAGR SPATPIVLVK QGHEPPTFIG WFFTWDPYKW TSHPSHKEVV
   721  DGSPAAASTI SEITAEVNNL RLSRWPGNGR AGAVALQALK GSQDSSENDL VRSPKSAGSR
   781  TSSSVSSTSA TINGGLRREQ LMHQAVEDLP EGVDPARREF YLSDSDFQDI FGKSKEEFYS
   841  MATWRQRQEK KQLGFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VILL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

stomach: 82 nTPM
small intestine: 52 nTPM
duodenum: 51 nTPM
colon: 36 nTPM
rectum: 21 nTPM
prostate: 15 nTPM

Single-cell type

foveolar cells: 432 nCPM
colonocytes: 188 nCPM
enterocytes: 180 nCPM
goblet cells: 113 nCPM
retinal pigment epithelial cells: 102 nCPM
respiratory secretory cells: 78 nCPM

Immune cell

MAIT T-cell: 7.3 nTPM
gdT-cell: 6.8 nTPM
T-reg: 5.8 nTPM
naive CD4 T-cell: 5.6 nTPM
naive B-cell: 4.6 nTPM
memory CD4 T-cell: 4.4 nTPM

Brain region

basal ganglia: 8.4 nTPM
amygdala: 8 nTPM
hippocampal formation: 8 nTPM
midbrain: 7.6 nTPM
medulla oblongata: 7.1 nTPM
hypothalamus: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VILL as an antibody target. Whether an autoantibody or antibody against VILL could matter depends on whether native VILL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VILL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VILL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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