Seroatlas · Human Serome Atlas

COTL1

Coactosin-like protein

Also known as: CLP, COTL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14019
Gene
COTL1
Ensembl
ENSG00000103187
Chromosome
16
Canonical length
142 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>Q14019|COTL1
     1  MATKIDKEAC RAAYNLVRDD GSAVIWVTFK YDGSTIVPGE QGAEYQHFIQ QCTDDVRLFA
    61  FVRFTTGDAM SKRSKFALIT WIGENVSGLQ RAKTGTDKTL VKEVVQNFAK EFVISDRKEL
   121  EEDFIKSELK KAGGANYDAQ TE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COTL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
350 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 350 nTPM
  • spleen: 315 nTPM
  • appendix: 279 nTPM
  • bone marrow: 258 nTPM
  • tonsil: 247 nTPM
  • kidney: 145 nTPM

Single-cell type

  • extravillous trophoblasts: 2,134 nCPM
  • neutrophils: 1,408 nCPM
  • monocytes: 1,347 nCPM
  • cdc: 1,072 nCPM
  • kupffer cells: 979 nCPM
  • platelets: 979 nCPM

Immune cell

  • non-classical monocyte: 4,601 nTPM
  • intermediate monocyte: 4,072 nTPM
  • eosinophil: 3,426 nTPM
  • total PBMC: 2,951 nTPM
  • classical monocyte: 2,442 nTPM
  • myeloid DC: 2,397 nTPM

Brain region

  • thalamus: 169 nTPM
  • medulla oblongata: 134 nTPM
  • white matter: 131 nTPM
  • pons: 128 nTPM
  • hypothalamus: 124 nTPM
  • basal ganglia: 119 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COTL1.

Disease | ImmuneIEDB

Conditions an epitope on COTL1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0.04
gnomAD missense Z
-0.13
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COTL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COTL1 as an antibody target. Whether an autoantibody or antibody against COTL1 could matter depends on whether native COTL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COTL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COTL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COTL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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