SCOC
Short coiled-coil protein
Also known as: HRIHFB2072, SCOC_HUMAN, SCOCO, UNC-69
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UIL1
- Gene
- SCOC
- Ensembl
- ENSG00000153130
- Chromosome
- 4
- Canonical length
- 159 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Golgi apparatus
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Canonical amino-acid sequenceUniProt
159 residues, UniProt reviewed canonical sequence.
>Q9UIL1|SCOC
1 MRRRVFSSQD WRASGWDGMG FFSRRTFCGR SGRSCRGQLV QVSRPEVSAG SLLLPAPQAE
61 DHSSRILYPR PKSLLPKMMN ADMDAVDAEN QVELEEKTRL INQVLELQHT LEDLSARVDA
121 VKEENLKLKS ENQVLGQYIE NLMSASSVFQ TTDTKSKRKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SCOC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 156 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 156 nTPM
- hypothalamus: 146 nTPM
- midbrain: 131 nTPM
- cerebral cortex: 114 nTPM
- amygdala: 110 nTPM
- hippocampal formation: 99 nTPM
Single-cell type
- early spermatids: 662 nCPM
- esophageal apical cells: 485 nCPM
- parietal cells: 302 nCPM
- late primary spermatocytes: 256 nCPM
- esophageal suprabasal cells: 204 nCPM
- cytotrophoblasts: 165 nCPM
Immune cell
- basophil: 48 nTPM
- naive CD4 T-cell: 47 nTPM
- NK-cell: 37 nTPM
- total PBMC: 37 nTPM
- memory B-cell: 37 nTPM
- naive CD8 T-cell: 37 nTPM
Brain region
- hypothalamus: 142 nTPM
- white matter: 134 nTPM
- pons: 130 nTPM
- midbrain: 116 nTPM
- thalamus: 111 nTPM
- medulla oblongata: 105 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.2
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.49
- DepMap mean gene effect
- 0.16
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Short coiled-coil protein
- Short coiled-coil protein
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SCOC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SCOC as an antibody target. Whether an autoantibody or antibody against SCOC could matter depends on whether native SCOC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SCOC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SCOC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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