Seroatlas · Human Serome Atlas

BECN2

Beclin-2

Also known as: BECN1P1, BECN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MW95
Gene: BECN2
Ensembl: ENSG00000196289
Chromosome: 1
Canonical length: 431 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Acts upstream of or within G protein-coupled receptor catabolic process; autophagy; and endosome to lysosome transport. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>A8MW95|BECN2
     1  MSSIRFLCQR CHQALKLSGS SESRSLPAAP APTSGQAEPG DTREPGVTTR EVTDAEEQQD
    61  GASSRSPPGD GSVSKGHANI FTLLGELGAM HMLSSIQKAA GDIFDIVSGQ AVVDHPLCEE
   121  CTDSLLEQLD IQLALTEADS QNYQRCLETG ELATSEDEAA ALRAELRDLE LEEARLVQEL
   181  EDVDRNNARA AADLQAAQAE AAELDQQERQ HYRDYSALKR QQLELLDQLG NVENQLQYAR
   241  VQRDRLKEIN CFTATFEIWV EGPLGVINNF RLGRLPTVRV GWNEINTAWG QAALLLLTLA
   301  NTIGLQFQRY RLIPCGNHSY LKSLTDDRTE LPLFCYGGQD VFLNNKYDRA MVAFLDCMQQ
   361  FKEEAEKGEL GLSLPYGIQV ETGLMEDVGG RGECYSIRTH LNTQELWTKA LKFMLINFKW
   421  SLIWVASRYQ K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BECN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

mesothelial cells: 0.3 nCPM
pituitary stem cells: 0.2 nCPM
early primary spermatocytes: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BECN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BECN2 as an antibody target. Whether an autoantibody or antibody against BECN2 could matter depends on whether native BECN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BECN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BECN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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