Seroatlas · Human Serome Atlas

FEZ1

Fasciculation and elongation protein zeta-1

Also known as: FEZ1_HUMAN, UNC-76

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99689
Gene
FEZ1
Ensembl
ENSG00000149557
Chromosome
11
Canonical length
392 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>Q99689|FEZ1
     1  MEAPLVSLDE EFEDLRPSCS EDPEEKPQCF YGSSPHHLED PSLSELENFS SEIISFKSME
    61  DLVNEFDEKL NVCFRNYNAK TENLAPVKNQ LQIQEEEETL QDEEVWDALT DNYIPSLSED
   121  WRDPNIEALN GNCSDTEIHE KEEEEFNEKS ENDSGINEEP LLTADQVIEE IEEMMQNSPD
   181  PEEEEEVLEE EDGGETSSQA DSVLLQEMQA LTQTFNNNWS YEGLRHMSGS ELTELLDQVE
   241  GAIRDFSEEL VQQLARRDEL EFEKEVKNSF ITVLIEVQNK QKEQRELMKK RRKEKGLSLQ
   301  SSRIEKGNQM PLKRFSMEGI SNILQSGIRQ TFGSSGTDKQ YLNTVIPYEK KASPPSVEDL
   361  QMLTNILFAM KEDNEKVPTL LTDYILKVLC PT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FEZ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
281 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 281 nTPM
  • midbrain: 151 nTPM
  • hippocampal formation: 106 nTPM
  • basal ganglia: 101 nTPM
  • amygdala: 97 nTPM
  • cerebral cortex: 96 nTPM

Single-cell type

  • oligodendrocytes: 350 nCPM
  • hofbauer cells: 210 nCPM
  • retinal horizontal cells: 154 nCPM
  • melanocytes: 140 nCPM
  • retinal amacrine cells: 109 nCPM
  • schwann cells: 100 nCPM

Immune cell

  • gdT-cell: 23 nTPM
  • MAIT T-cell: 16 nTPM
  • naive CD8 T-cell: 5.5 nTPM
  • memory CD8 T-cell: 5.1 nTPM
  • total PBMC: 4.4 nTPM
  • NK-cell: 1 nTPM

Brain region

  • white matter: 281 nTPM
  • medulla oblongata: 226 nTPM
  • cerebellum: 226 nTPM
  • basal ganglia: 217 nTPM
  • spinal cord: 207 nTPM
  • midbrain: 206 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.75
gnomAD missense Z
1.38
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FEZ1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FEZ1 as an antibody target. Whether an autoantibody or antibody against FEZ1 could matter depends on whether native FEZ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FEZ1 is annotated at the cell surface, where native FEZ1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FEZ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FEZ1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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