Seroatlas · Human Serome Atlas

ATXN7L3

Ataxin-7-like protein 3

Also known as: AT7L3_HUMAN, DKFZp761G2113

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14CW9
Gene
ATXN7L3
Ensembl
ENSG00000087152
Chromosome
17
Canonical length
347 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Plasma membrane

OverviewNCBI Gene

Enables transcription coactivator activity. Involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Located in nucleus. Part of DUBm complex and SAGA complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q14CW9|ATXN7L3
     1  MKMEEMSLSG LDNSKLEAIA QEIYADLVED SCLGFCFEVH RAVKCGYFFL DDTDPDSMKD
    61  FEIVDQPGLD IFGQVFNQWK SKECVCPNCS RSIAASRFAP HLEKCLGMGR NSSRIANRRI
   121  ANSNNMNKSE SDQEDNDDIN DNDWSYGSEK KAKKRKSDKN PNSPRRSKSL KHKNGELSNS
   181  DPFKYNNSTG ISYETLGPEE LRSLLTTQCG VISEHTKKMC TRSLRCPQHT DEQRRTVRIY
   241  FLGPSAVLPE VESSLDNDSF DMTDSQALIS RLQWDGSSDL SPSDSGSSKT SENQGWGLGT
   301  NSSESRKTKK KKSHLSLVGT ASGLGSNKKK KPKPPAPPTP SIYDDIN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATXN7L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
92 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 92 nTPM
  • amygdala: 63 nTPM
  • hippocampal formation: 54 nTPM
  • bone marrow: 42 nTPM
  • hypothalamus: 41 nTPM
  • thymus: 39 nTPM

Single-cell type

  • neutrophils: 59 nCPM
  • late spermatids: 59 nCPM
  • platelets: 55 nCPM
  • tuft cells: 46 nCPM
  • esophageal apical cells: 35 nCPM
  • megakaryocytes: 31 nCPM

Immune cell

  • neutrophil: 2.5 nTPM
  • naive B-cell: 2.4 nTPM
  • gdT-cell: 1.7 nTPM
  • plasmacytoid DC: 1.6 nTPM
  • eosinophil: 1.5 nTPM
  • memory B-cell: 1.4 nTPM

Brain region

  • cerebral cortex: 138 nTPM
  • pons: 117 nTPM
  • white matter: 102 nTPM
  • amygdala: 98 nTPM
  • basal ganglia: 98 nTPM
  • thalamus: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
2.05
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATXN7L3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATXN7L3 as an antibody target. Whether an autoantibody or antibody against ATXN7L3 could matter depends on whether native ATXN7L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATXN7L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATXN7L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATXN7L3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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