Ubiquitin carboxyl-terminal hydrolase
IPR050185
Definition
The ubiquitin carboxyl-terminal hydrolase family, also known as deubiquitinating enzymes (DUBs), plays a crucial role in various cellular processes by cleaving ubiquitin from ubiquitinated proteins, thus regulating protein turnover and preventing degradation [[cite:PMID:25404403], [cite:PMID:28604766], [cite:PMID:30514904]].. Members of this family are involved in cell cycle regulation, DNA repair, transcriptional regulation, autophagy, and signal transduction [[cite:PMID:30514904], [cite:PMID:39589880]]. They exhibit specificity for different ubiquitin linkages and substrates, including histones, signalling receptors, and structural proteins, thereby influencing pathways such as NF-kappa-B activation, TGF-beta receptor signaling, and the spindle assembly checkpoint. Their activities contribute to the maintenance of protein homeostasis, genomic stability, and cellular response to stress and damage.
24 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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