Seroatlas · Human Serome Atlas

AASDHPPT

L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Also known as: AASD-PPT, ACPS, ADPPT_HUMAN, CGI-80, LYS5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRN7
Gene
AASDHPPT
Ensembl
ENSG00000149313
Chromosome
11
Canonical length
309 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q9NRN7|AASDHPPT
     1  MVFPAKRFCL VPSMEGVRWA FSCGTWLPSR AEWLLAVRSI QPEEKERIGQ FVFARDAKAA
    61  MAGRLMIRKL VAEKLNIPWN HIRLQRTAKG KPVLAKDSSN PYPNFNFNIS HQGDYAVLAA
   121  EPELQVGIDI MKTSFPGRGS IPEFFHIMKR KFTNKEWETI RSFKDEWTQL DMFYRNWALK
   181  ESFIKAIGVG LGFELQRLEF DLSPLNLDIG QVYKETRLFL DGEEEKEWAF EESKIDEHHF
   241  VAVALRKPDG SRHQDVPSQD DSKPTQRQFT ILNFNDLMSS AVPMTPEDPS FWDCFCFTEE
   301  IPIRNGTKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AASDHPPT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 48 nTPM
  • hypothalamus: 38 nTPM
  • cerebellum: 38 nTPM
  • testis: 35 nTPM
  • basal ganglia: 34 nTPM
  • hippocampal formation: 33 nTPM

Single-cell type

  • early spermatids: 450 nCPM
  • late primary spermatocytes: 193 nCPM
  • cytotrophoblasts: 95 nCPM
  • migrating cytotrophoblasts: 82 nCPM
  • cardiomyocytes: 80 nCPM
  • extravillous trophoblasts: 78 nCPM

Immune cell

  • basophil: 64 nTPM
  • NK-cell: 32 nTPM
  • T-reg: 31 nTPM
  • MAIT T-cell: 29 nTPM
  • non-classical monocyte: 28 nTPM
  • intermediate monocyte: 28 nTPM

Brain region

  • cerebral cortex: 54 nTPM
  • hypothalamus: 51 nTPM
  • white matter: 49 nTPM
  • basal ganglia: 46 nTPM
  • spinal cord: 45 nTPM
  • hippocampal formation: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.03
gnomAD missense Z
0.46
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • 4'-phosphopantetheinyl transferase domain
  • 4'-phosphopantetheinyl transferase domain superfamily
  • Phosphopantetheinyl Transferase Superfamily
  • 4'-phosphopantetheinyl transferase, N-terminal
  • 4'-phosphopantetheinyl transferase superfamily
  • 4'-phosphopantetheinyl transferase, N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AASDHPPT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AASDHPPT as an antibody target. Whether an autoantibody or antibody against AASDHPPT could matter depends on whether native AASDHPPT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AASDHPPT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AASDHPPT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AASDHPPT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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