Seroatlas · Human Serome Atlas

ATXN7L1

Ataxin-7-like protein 1

Also known as: AT7L1_HUMAN, ATXN7L4, KIAA1218, MGC33190

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULK2
Gene: ATXN7L1
Ensembl: ENSG00000146776
Chromosome: 7
Canonical length: 861 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for ATXN7L1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

861 residues, UniProt reviewed canonical sequence.

>Q9ULK2|ATXN7L1
     1  MTSERSRIPC LSAAAAEGTG KKQQEGRAMA TLDRKVPSPE AFLGKPWSSW IDAAKLHCSD
    61  NVDLEEAGKE GGKSREVMRL NKEDMHLFGH YPAHDDFYLV VCSACNQVVK PQVFQSHCER
   121  RHGSMCRPSP SPVSPASNPR TSLVQVKTKA CLSGHHSASS TSKPFKTPKD NLLTSSSKQH
   181  TVFPAKGSRD KPCVPVPVVS LEKIPNLVKA DGANVKMNST TTTAVSASST SSSAVSTPPL
   241  IKPVLMSKSV PPSPEKILNG KGILPTTIDK KHQNGTKNSN KPYRRLSERE FDPNKHCGVL
   301  DPETKKPCTR SLTCKTHSLS HRRAVPGRKK QFDLLLAEHK AKSREKEVKD KEHLLTSTRE
   361  ILPSQSGPAQ DSLLGSSGSS GPEPKVASPA KSRPPNSVLP RPSSANSISS STSSNHSGHT
   421  PEPPLPPVGG DLASRLSSDE GEMDGADESE KLDCQFSTHH PRPLAFCSFG SRLMGRGYYV
   481  FDRRWDRFRF ALNSMVEKHL NSQMWKKIPP AADSPLPSPA AHITTPVPAS VLQPFSNPSA
   541  VYLPSAPISS RLTSSYIMTS AMLSNAAFVT SPDPSALMSH TTAFPHVAAT LSIMDSTFKA
   601  PSAVSPIPAV IPSPSHKPSK TKTSKSSKVK DLSTRSDESP SNKKRKPQSS TSSSSSSSSS
   661  SLQTSLSSPL SGPHKKNCVL NASSALNSYQ AAPPYNSLSV HNSNNGVSPL SAKLEPSGRT
   721  SLPGGPADIV RQVGAVGGSS DSCPLSVPSL ALHAGDLSLA SHNAVSSLPL SFDKSEGKKR
   781  KNSSSSSKAC KITKMPGMNS VHKKNPPSLL APVPDPVNST SSRQVGKNSS LALSQSSPSS
   841  ISSPGHSRQN TNRTGRIRTL P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATXN7L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 9.7 nTPM

Expression across tissuesHPA

Tissue

testis: 9.7 nTPM
thymus: 9.4 nTPM
kidney: 6.8 nTPM
cervix: 6.2 nTPM
liver: 6.2 nTPM
lymph node: 6 nTPM

Single-cell type

proximal tubule cells: 372 nCPM
sertoli cells: 359 nCPM
choroid plexus epithelial cells: 301 nCPM
somatotrophs: 279 nCPM
adrenal cortex cells: 271 nCPM
lactotrophs: 261 nCPM

Immune cell

T-reg: 14 nTPM
naive CD4 T-cell: 6.9 nTPM
memory CD4 T-cell: 6.5 nTPM
memory CD8 T-cell: 5.6 nTPM
intermediate monocyte: 4.4 nTPM
NK-cell: 4.4 nTPM

Brain region

cerebellum: 23 nTPM
cerebral cortex: 23 nTPM
basal ganglia: 19 nTPM
white matter: 18 nTPM
hypothalamus: 17 nTPM
midbrain: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 2.3
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of ATXN7L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

USP22

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATXN7L1 as an antibody target. Whether an autoantibody or antibody against ATXN7L1 could matter depends on whether native ATXN7L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATXN7L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATXN7L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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