Seroatlas · Human Serome Atlas

SERTAD1

SERTA domain-containing protein 1

Also known as: SEI1, SRTD1_HUMAN, TRIP-Br1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHV2
Gene: SERTAD1
Ensembl: ENSG00000197019
Chromosome: 19
Canonical length: 236 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable transcription coactivator activity. Acts upstream of or within negative regulation of cell growth. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q9UHV2|SERTAD1
     1  MLSKGLKRKR EEEEEKEPLA VDSWWLDPGH TAVAQAPPAV ASSSLFDLSV LKLHHSLQQS
    61  EPDLRHLVLV VNTLRRIQAS MAPAAALPPV PSPPAAPSVA DNLLASSDAA LSASMASLLE
   121  DLSHIEGLSQ APQPLADEGP PGRSIGGAAP SLGALDLLGP ATGCLLDDGL EGLFEDIDTS
   181  MYDNELWAPA SEGLKPGPED GPGKEEAPEL DEAELDYLMD VLVGTQALER PPGPGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERTAD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 27 nTPM
adipose tissue: 26 nTPM
choroid plexus: 22 nTPM
lung: 22 nTPM
heart muscle: 21 nTPM
esophagus: 19 nTPM

Single-cell type

esophageal apical cells: 709 nCPM
epididymal basal cells: 448 nCPM
breast secretory cells: 421 nCPM
endometrial secretory cells: 311 nCPM
breast lactating cells: 299 nCPM
smooth muscle cells: 265 nCPM

Immune cell

myeloid DC: 26 nTPM
plasmacytoid DC: 24 nTPM
basophil: 23 nTPM
classical monocyte: 22 nTPM
intermediate monocyte: 20 nTPM
non-classical monocyte: 20 nTPM

Brain region

cerebral cortex: 17 nTPM
thalamus: 13 nTPM
cerebellum: 12 nTPM
hippocampal formation: 11 nTPM
medulla oblongata: 11 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0.32
gnomAD missense Z: 1.15
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription coactivator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERTAD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERTAD1 as an antibody target. Whether an autoantibody or antibody against SERTAD1 could matter depends on whether native SERTAD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERTAD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERTAD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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