Seroatlas · Human Serome Atlas

SIMC1

SUMO-interacting motif-containing protein 1

Also known as: C5orf25, FLJ44216, OOMA1, PLEIAD, SIMC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDZ2
Gene: SIMC1
Ensembl: ENSG00000170085
Chromosome: 5
Canonical length: 872 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Enables SUMO polymer binding activity and peptidase inhibitor activity. Located in PML body and sarcomere. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

872 residues, UniProt reviewed canonical sequence.

>Q8NDZ2|SIMC1
     1  MAPASASGED LRKLPTMAEV NGEQDFIDLT RETRPRTKDR SGLYVIDLTR AEGENRPIAT
    61  LDLTLEPVTP SQKEPTSLQT CASLSGKAVM EGHVDRSSQP TARRIINSDP VDLDLVEENT
   121  FVGPPPATSI SGGSVYPTEP NCSSATFTGN LSFLASLQLS SDVSSLSPTS NNSRSSSSSS
   181  NQKAPLPCPQ QDVSRPPQAL PCPLRPLPCP PRASPCPPRA SSCPPRALSC PSQTMQCQLP
   241  ALTHPPQEVP CPRQNIPGPP QDSLGLPQDV PGLPQSILHP QDVAYLQDMP RSPGDVPQSP
   301  SDVSPSPDAP QSPGGMPHLP GDVLHSPGDM PHSSGDVTHS PRDIPHLPGD RPDFTQNDVQ
   361  NRDMPMDISA LSSPSCSPSP QSETPLEKVP WLSVMETPAR KEISLSEPAK PGSAHVQSRT
   421  PQGGLYNRPC LHRLKYFLRP PVHHLFFQTL IPDKDTRENK GQKLEPIPHR RLRMVTNTIE
   481  ENFPLGTVQF LMDFVSPQHY PPREIVAHII QKILLSGSET VDVLKEAYML LMKIQQLHPA
   541  NAKTVEWDWK LLTYVMEEEG QTLPGRVLFL RYVVQTLEDD FQQTLRRQRQ HLQQSIANMV
   601  LSCDKQPHNV RDVIKWLVKA VTEDGLTQPP NGNQTSSGTG ILKASSSHPS SQPNLTKNTN
   661  QLIVCQLQRM LSIAVEVDRT PTCSSNKIAE MMFGFVLDIP ERSQREMFFT TMESHLLRCK
   721  VLEIIFLHSC ETPTRLPLSL AQALYFLNNS TSLLKCQSDK SQWQTWDELV EHLQFLLSSY
   781  QHVLREHLRS SVIDRKDLII KRIKPKPQQG DDITVVDVEK QIEAFRSRLI QMLGEPLVPQ
   841  LQDKVHLLKL LLFYAADLNP DAEPFQKGWS GS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIMC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

ovary: 39 nTPM
testis: 31 nTPM
adrenal gland: 22 nTPM
pituitary gland: 12 nTPM
fallopian tube: 12 nTPM
cervix: 11 nTPM

Single-cell type

adrenal cortex cells: 291 nCPM
sertoli cells: 185 nCPM
early primary spermatocytes: 173 nCPM
ovarian stromal cells: 154 nCPM
gonadotrophs: 143 nCPM
choroid plexus epithelial cells: 137 nCPM

Immune cell

NK-cell: 7.3 nTPM
basophil: 7.1 nTPM
eosinophil: 7.1 nTPM
myeloid DC: 5.2 nTPM
memory B-cell: 4.4 nTPM
naive B-cell: 4.2 nTPM

Brain region

hypothalamus: 19 nTPM
choroid plexus: 18 nTPM
cerebellum: 16 nTPM
basal ganglia: 16 nTPM
cerebral cortex: 16 nTPM
amygdala: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Elongin BC-PRC2 Interaction & Viral Restriction

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIMC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIMC1 as an antibody target. Whether an autoantibody or antibody against SIMC1 could matter depends on whether native SIMC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIMC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIMC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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