Seroatlas · Human Serome Atlas

SENP2

Sentrin-specific protease 2

Also known as: AXAM2, DKFZp762A2316, KIAA1331, SENP2_HUMAN, SMT3IP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HC62
Gene
SENP2
Ensembl
ENSG00000163904
Chromosome
3
Canonical length
589 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

589 residues, UniProt reviewed canonical sequence.

>Q9HC62|SENP2
     1  MYRWLVRILG TIFRFCDRSV PPARALLKRR RSDSTLFSTV DTDEIPAKRP RLDCFIHQVK
    61  NSLYNAASLF GFPFQLTTKP MVTSACNGTR NVAPSGEVFS NSSSCELTGS GSWNNMLKLG
   121  NKSPNGISDY PKIRVTVTRD QPRRVLPSFG FTLNSEGCNR RPGGRRHSKG NPESSLMWKP
   181  QEQAVTEMIS EESGKGLRRP HCTVEEGVQK EEREKYRKLL ERLKESGHGN SVCPVTSNYH
   241  SSQRSQMDTL KTKGWGEEQN HGVKTTQFVP KQYRLVETRG PLCSLRSEKR CSKGKITDTE
   301  TMVGIRFENE SRRGYQLEPD LSEEVSARLR LGSGSNGLLR RKVSIIETKE KNCSGKERDR
   361  RTDDLLELTE DMEKEISNAL GHGPQDEILS SAFKLRITRG DIQTLKNYHW LNDEVINFYM
   421  NLLVERNKKQ GYPALHVFST FFYPKLKSGG YQAVKRWTKG VNLFEQEIIL VPIHRKVHWS
   481  LVVIDLRKKC LKYLDSMGQK GHRICEILLQ YLQDESKTKR NSDLNLLEWT HHSMKPHEIP
   541  QQLNGSDCGM FTCKYADYIS RDKPITFTQH QMPLFRKKMV WEILHQQLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SENP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 18 nTPM
  • testis: 14 nTPM
  • basal ganglia: 14 nTPM
  • cerebral cortex: 13 nTPM
  • cerebellum: 13 nTPM
  • tongue: 12 nTPM

Single-cell type

  • early spermatids: 275 nCPM
  • late primary spermatocytes: 227 nCPM
  • neutrophils: 158 nCPM
  • neutrophil progenitors: 151 nCPM
  • somatotrophs: 124 nCPM
  • lactotrophs: 119 nCPM

Immune cell

  • basophil: 4.8 nTPM
  • neutrophil: 3.4 nTPM
  • eosinophil: 2.6 nTPM
  • NK-cell: 2.3 nTPM
  • plasmacytoid DC: 2 nTPM
  • naive B-cell: 1.9 nTPM

Brain region

  • basal ganglia: 27 nTPM
  • cerebral cortex: 24 nTPM
  • hypothalamus: 24 nTPM
  • white matter: 23 nTPM
  • midbrain: 23 nTPM
  • thalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.98
gnomAD missense Z
1.87
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SENP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SENP2 as an antibody target. Whether an autoantibody or antibody against SENP2 could matter depends on whether native SENP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SENP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SENP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SENP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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