Seroatlas · Human Serome Atlas

RWDD3

RWD domain-containing protein 3

Also known as: DKFZP566K023, RSUME, RWDD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3V2
Gene: RWDD3
Ensembl: ENSG00000122481
Chromosome: 1
Canonical length: 267 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in negative regulation of NF-kappaB transcription factor activity; positive regulation of hypoxia-inducible factor-1alpha signaling pathway; and positive regulation of protein sumoylation. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

267 residues, UniProt reviewed canonical sequence.

>Q9Y3V2|RWDD3
     1  MAEPVQEELS VLAAIFCRPH EWEVLSRSET DGTVFRIHTK AEGFMDVDIP LELVFHLPVN
    61  YPSCLPGISI NSEQLTRAQC VTVKENLLEQ AESLLSEPMV HELVLWIQQN LRHILSQPET
   121  GSGSEKCTFS TSTTMDDGLW ITLLHLDHMR AKTKYVKIVE KWASDLRLTG RLMFMGKIIL
   181  ILLQGDRNNL KEYLILQKTS KVDVDSSGKK CKEKMISVLF ETKVQTEHKR FLAFEVKEYS
   241  ALDELQKEFE TAGLKKLFSE FVLALVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RWDD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 12 nTPM
skeletal muscle: 9.8 nTPM
cervix: 9.3 nTPM
epididymis: 9.3 nTPM
fallopian tube: 9.2 nTPM
urinary bladder: 9.1 nTPM

Single-cell type

astrocytes: 52 nCPM
bergmann glia: 40 nCPM
oligodendrocyte progenitor cells: 36 nCPM
oligodendrocytes: 33 nCPM
microglia: 32 nCPM
choroid plexus epithelial cells: 29 nCPM

Immune cell

memory B-cell: 28 nTPM
naive B-cell: 28 nTPM
T-reg: 25 nTPM
basophil: 25 nTPM
eosinophil: 20 nTPM
naive CD4 T-cell: 19 nTPM

Brain region

white matter: 6.5 nTPM
cerebral cortex: 5.3 nTPM
basal ganglia: 5.2 nTPM
cerebellum: 4.6 nTPM
hypothalamus: 4.5 nTPM
amygdala: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of NF-kappaB transcription factor activity
positive regulation of protein sumoylation
positive regulation of hypoxia-inducible factor-1alpha signaling pathway

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RWDD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RWDD3 as an antibody target. Whether an autoantibody or antibody against RWDD3 could matter depends on whether native RWDD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RWDD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RWDD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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