Seroatlas · Human Serome Atlas

RANGAP1

Ran GTPase-activating protein 1

Also known as: Fug1, KIAA1835, RAGP1_HUMAN, SD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P46060
Gene: RANGAP1
Ensembl: ENSG00000100401
Chromosome: 22
Canonical length: 587 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nuclear membrane,Vesicles,Cytosol,Flagellar centriole
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

587 residues, UniProt reviewed canonical sequence.

>P46060|RANGAP1
     1  MASEDIAKLA ETLAKTQVAG GQLSFKGKSL KLNTAEDAKD VIKEIEDFDS LEALRLEGNT
    61  VGVEAARVIA KALEKKSELK RCHWSDMFTG RLRTEIPPAL ISLGEGLITA GAQLVELDLS
   121  DNAFGPDGVQ GFEALLKSSA CFTLQELKLN NCGMGIGGGK ILAAALTECH RKSSAQGKPL
   181  ALKVFVAGRN RLENDGATAL AEAFRVIGTL EEVHMPQNGI NHPGITALAQ AFAVNPLLRV
   241  INLNDNTFTE KGAVAMAETL KTLRQVEVIN FGDCLVRSKG AVAIADAIRG GLPKLKELNL
   301  SFCEIKRDAA LAVAEAMADK AELEKLDLNG NTLGEEGCEQ LQEVLEGFNM AKVLASLSDD
   361  EDEEEEEEGE EEEEEAEEEE EEDEEEEEEE EEEEEEEPQQ RGQGEKSATP SRKILDPNTG
   421  EPAPVLSSPP PADVSTFLAF PSPEKLLRLG PKSSVLIAQQ TDTSDPEKVV SAFLKVSSVF
   481  KDEATVRMAV QDAVDALMQK AFNSSSFNSN TFLTRLLVHM GLLKSEDKVK AIANLYGPLM
   541  ALNHMVQQDY FPKALAPLLL AFVTKPNSAL ESCSFARHSL LQTLYKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RANGAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 157 nTPM

Expression across tissuesHPA

Tissue

testis: 157 nTPM
cerebral cortex: 96 nTPM
skin: 79 nTPM
hypothalamus: 74 nTPM
liver: 72 nTPM
basal ganglia: 69 nTPM

Single-cell type

late spermatids: 3,236 nCPM
early spermatids: 329 nCPM
esophageal basal cells: 88 nCPM
pancreatic acinar cells: 76 nCPM
suprabasal keratinocytes: 73 nCPM
esophageal suprabasal cells: 71 nCPM

Immune cell

non-classical monocyte: 13 nTPM
MAIT T-cell: 9.5 nTPM
T-reg: 9.5 nTPM
intermediate monocyte: 8.9 nTPM
memory CD4 T-cell: 8.2 nTPM
gdT-cell: 8.1 nTPM

Brain region

white matter: 174 nTPM
pons: 172 nTPM
cerebral cortex: 164 nTPM
medulla oblongata: 150 nTPM
hypothalamus: 131 nTPM
thalamus: 124 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RANGAP1.

Disease | ImmuneIEDB

Conditions an epitope on RANGAP1 was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.03
gnomAD missense Z: 1.14
DepMap mean gene effect: -1.57
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat
Leucine-rich repeat domain superfamily
Leucine Rich repeat
Ran-GTPase activating protein 1, C-terminal
Ran GTPase-activating protein
Ran-GTPase activating protein 1, C-terminal domain superfamily
RanGAP1 C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RANGAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RANGAP1 as an antibody target. Whether an autoantibody or antibody against RANGAP1 could matter depends on whether native RANGAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RANGAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RANGAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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