Seroatlas · Human Serome Atlas

SENP1

Sentrin-specific protease 1

Also known as: SENP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P0U3
Gene
SENP1
Ensembl
ENSG00000079387
Chromosome
12
Canonical length
644 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Focal adhesion sites

OverviewNCBI Gene

This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

644 residues, UniProt reviewed canonical sequence.

>Q9P0U3|SENP1
     1  MDDIADRMRM DAGEVTLVNH NSVFKTHLLP QTGFPEDQLS LSDQQILSSR QGHLDRSFTC
    61  STRSAAYNPS YYSDNPSSDS FLGSGDLRTF GQSANGQWRN STPSSSSSLQ KSRNSRSLYL
   121  ETRKTSSGLS NSFAGKSNHH CHVSAYEKSF PIKPVPSPSW SGSCRRSLLS PKKTQRRHVS
   181  TAEETVQEEE REIYRQLLQM VTGKQFTIAK PTTHFPLHLS RCLSSSKNTL KDSLFKNGNS
   241  CASQIIGSDT SSSGSASILT NQEQLSHSVY SLSSYTPDVA FGSKDSGTLH HPHHHHSVPH
   301  QPDNLAASNT QSEGSDSVIL LKVKDSQTPT PSSTFFQAEL WIKELTSVYD SRARERLRQI
   361  EEQKALALQL QNQRLQEREH SVHDSVELHL RVPLEKEIPV TVVQETQKKG HKLTDSEDEF
   421  PEITEEMEKE IKNVFRNGNQ DEVLSEAFRL TITRKDIQTL NHLNWLNDEI INFYMNMLME
   481  RSKEKGLPSV HAFNTFFFTK LKTAGYQAVK RWTKKVDVFS VDILLVPIHL GVHWCLAVVD
   541  FRKKNITYYD SMGGINNEAC RILLQYLKQE SIDKKRKEFD TNGWQLFSKK SQEIPQQMNG
   601  SDCGMFACKY ADCITKDRPI NFTQQHMPYF RKRMVWEILH RKLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SENP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • testis: 58 nTPM
  • salivary gland: 31 nTPM
  • bone marrow: 14 nTPM
  • tonsil: 12 nTPM
  • thymus: 11 nTPM
  • lymph node: 11 nTPM

Single-cell type

  • early primary spermatocytes: 120 nCPM
  • late primary spermatocytes: 73 nCPM
  • lactotrophs: 54 nCPM
  • cone photoreceptor cells: 52 nCPM
  • myonuclei: 51 nCPM
  • differentiating spermatogonia: 46 nCPM

Immune cell

  • eosinophil: 2.9 nTPM
  • MAIT T-cell: 2.1 nTPM
  • T-reg: 1.9 nTPM
  • naive B-cell: 1.8 nTPM
  • gdT-cell: 1.6 nTPM
  • memory CD4 T-cell: 1.6 nTPM

Brain region

  • cerebellum: 22 nTPM
  • hypothalamus: 15 nTPM
  • white matter: 15 nTPM
  • basal ganglia: 13 nTPM
  • pons: 12 nTPM
  • cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
2
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SENP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SENP1 as an antibody target. Whether an autoantibody or antibody against SENP1 could matter depends on whether native SENP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SENP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SENP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SENP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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