Seroatlas · Human Serome Atlas

COG4

Conserved oligomeric Golgi complex subunit 4

Also known as: COG4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9E3
Gene: COG4
Canonical length: 785 aa
Protein class: Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for COG4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

785 residues, UniProt reviewed canonical sequence.

>Q9H9E3|COG4
     1  MADLDSPPKL SGVQQPSEGV GGGRCSEISA ELIRSLTELQ ELEAVYERLC GEEKVVEREL
    61  DALLEQQNTI ESKMVTLHRM GPNLQLIEGD AKQLAGMITF TCNLAENVSS KVRQLDLAKN
   121  RLYQAIQRAD DILDLKFCMD GVQTALRSED YEQAAAHTHR YLCLDKSVIE LSRQGKEGSM
   181  IDANLKLLQE AEQRLKAIVA EKFAIATKEG DLPQVERFFK IFPLLGLHEE GLRKFSEYLC
   241  KQVASKAEEN LLMVLGTDMS DRRAAVIFAD TLTLLFEGIA RIVETHQPIV ETYYGPGRLY
   301  TLIKYLQVEC DRQVEKVVDK FIKQRDYHQQ FRHVQNNLMR NSTTEKIEPR ELDPILTEVT
   361  LMNARSELYL RFLKKRISSD FEVGDSMASE EVKQEHQKCL DKLLNNCLLS CTMQELIGLY
   421  VTMEEYFMRE TVNKAVALDT YEKGQLTSSM VDDVFYIVKK CIGRALSSSS IDCLCAMINL
   481  ATTELESDFR DVLCNKLRMG FPATTFQDIQ RGVTSAVNIM HSSLQQGKFD TKGIESTDEA
   541  KMSFLVTLNN VEVCSENIST LKKTLESDCT KLFSQGIGGE QAQAKFDSCL SDLAAVSNKF
   601  RDLLQEGLTE LNSTAIKPQV QPWINSFFSV SHNIEEEEFN DYEANDPWVQ QFILNLEQQM
   661  AEFKASLSPV IYDSLTGLMT SLVAVELEKV VLKSTFNRLG GLQFDKELRS LIAYLTTVTT
   721  WTIRDKFARL SQMATILNLE RVTEILDYWG PNSGPLTWRL TPAEVRQVLA LRIDFRSEDI
   781  KRLRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 60 nTPM
tongue: 44 nTPM
esophagus: 28 nTPM
choroid plexus: 27 nTPM
heart muscle: 24 nTPM
parathyroid gland: 23 nTPM

Single-cell type

tuft cells: 81 nCPM
esophageal apical cells: 74 nCPM
cytotrophoblasts: 69 nCPM
early primary spermatocytes: 65 nCPM
esophageal suprabasal cells: 60 nCPM
myonuclei: 53 nCPM

Immune cell

myeloid DC: 31 nTPM
non-classical monocyte: 31 nTPM
intermediate monocyte: 26 nTPM
total PBMC: 24 nTPM
classical monocyte: 24 nTPM
eosinophil: 20 nTPM

Brain region

thalamus: 14 nTPM
cerebellum: 14 nTPM
medulla oblongata: 13 nTPM
midbrain: 13 nTPM
pons: 12 nTPM
spinal cord: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COG4.

Disease | AllUniProt

Conditions COG4 is implicated in, by any mechanism.

Congenital disorder of glycosylation 2J (CDG2J) MIM:613489
Saul-Wilson syndrome (SWILS) MIM:618150

Disease | GeneticClinVar

36 pathogenic / likely-pathogenic of 479 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

COG4-congenital disorder of glycosylation
Microcephalic osteodysplastic dysplasia, Saul-Wilson type
COG4-Related Disorders
Fetal anomalies with a likely genetic cause
See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0
gnomAD missense Z: -0.28
DepMap mean gene effect: -0.45
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

COG4 transport protein, middle alpha-helical bundle
Conserved oligomeric Golgi complex subunit 4, N-terminal
Conserved oligomeric Golgi complex subunit 4
Conserved oligomeric Golgi complex subunit 4, C-terminal
COG4 transport protein, middle alpha-helical bundle
Conserved oligomeric Golgi complex subunit 4, C-terminal
Conserved oligomeric Golgi complex subunit 4, N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COG4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

STX5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COG4 as an antibody target. Whether an autoantibody or antibody against COG4 could matter depends on whether native COG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COG4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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