Seroatlas · Human Serome Atlas

BNIP1

Vesicle transport protein SEC20

Also known as: Nip1, SEC20, SEC20_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12981
Gene
BNIP1
Ensembl
ENSG00000113734
Chromosome
5
Canonical length
228 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q12981|BNIP1
     1  MAAPQDVHVR ICNQEIVKFD LEVKALIQDI RDCSGPLSAL TELNTKVKEK FQQLRHRIQD
    61  LEQLAKEQDK ESEKQLLLQE VENHKKQMLS NQASWRKANL TCKIAIDNLE KAELLQGGDL
   121  LRQRKTTKES LAQTSSTITE SLMGISRMMA QQVQQSEEAM QSLVTSSRTI LDANEEFKSM
   181  SGTIQLGRKL ITKYNRRELT DKLLIFLALA LFLATVLYIV KKRLFPFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BNIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 32 nTPM
  • pancreas: 18 nTPM
  • tongue: 15 nTPM
  • testis: 14 nTPM
  • skeletal muscle: 13 nTPM
  • choroid plexus: 13 nTPM

Single-cell type

  • oocytes: 78 nCPM
  • late primary spermatocytes: 51 nCPM
  • syncytiotrophoblasts: 44 nCPM
  • cytotrophoblasts: 33 nCPM
  • migrating cytotrophoblasts: 31 nCPM
  • esophageal basal cells: 29 nCPM

Immune cell

  • gdT-cell: 17 nTPM
  • plasmacytoid DC: 16 nTPM
  • memory CD4 T-cell: 15 nTPM
  • MAIT T-cell: 14 nTPM
  • T-reg: 14 nTPM
  • myeloid DC: 13 nTPM

Brain region

  • hypothalamus: 14 nTPM
  • thalamus: 13 nTPM
  • pons: 13 nTPM
  • midbrain: 13 nTPM
  • white matter: 13 nTPM
  • medulla oblongata: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BNIP1.

Disease | AllUniProt

Conditions BNIP1 is implicated in, by any mechanism.

  • Spondyloepiphyseal dysplasia, Holling type (SEDH) MIM:621345

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.47
DepMap mean gene effect
-0.67
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Sec20
  • Sec20, C-terminal
  • Sec20

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BNIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BNIP1 as an antibody target. Whether an autoantibody or antibody against BNIP1 could matter depends on whether native BNIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BNIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BNIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BNIP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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