Seroatlas · Human Serome Atlas

SCFD2

Sec1 family domain-containing protein 2

Also known as: FLJ39514, SCFD2_HUMAN, STXBP1L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WU76
Gene: SCFD2
Ensembl: ENSG00000184178
Chromosome: 4
Canonical length: 684 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in intracellular protein transport and vesicle-mediated transport. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

684 residues, UniProt reviewed canonical sequence.

>Q8WU76|SCFD2
     1  MSASGVLSFT QQGWEQVLAK VKRAVVYLDA ACAESLHWGC GSTRLLEAVG GPDCHLREFE
    61  PDAIGGGAKQ PKAVFVLSCL LKGRTVEILR DIICRSHFQY CVVVTTVSHA VHLTANHVPA
   121  AAAAEMEGQQ PVFEQLEEKL CEWMGNMNYT AEVFHVPLLL APVAPHFALT PAFASLFPLL
   181  PQDVHLLNSA RPDKRKLGSL GDVDSTTLTP ELLLQIRCLV SGLSSLCEHL GVREECFAVG
   241  SLSQVIAADL ANYAPAKNRK KTAAGRASVV FVDRTLDLTG AVGHHGDNLV EKIISALPQL
   301  PGHTNDVMVN MIALTALHTE EENYNVVAPG CLSQSSDTTA KALWEALLNT KHKEAVMEVR
   361  RHLVEAASRE NLPIKMSMGR VTPGQLMSYI QLFKNNLKAL MNHCGLLQLG LATAQTLKHP
   421  QTAKWDNFLA FERLLLQSIG ESAMSVVLNQ LLPMIKPVTQ RTNEDYSPEE LLILLIYIYS
   481  VTGELTVDKD LCEAEEKVKK ALAQVFCEES GLSPLLQKIT DWDSSINLTF HKSKIAVDEL
   541  FTSLRDIAGA RSLLKQFKSV YVPGNHTHQA SYKPLLKQVV EEIFHPERPD SVDIEHMSSG
   601  LTDLLKTGFS MFMKVSRPHP SDYPLLILFV VGGVTVSEVK MVKDLVASLK PGTQVIVLST
   661  RLLKPLNIPE LLFATDRLHP DLGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCFD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 8.2 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 8.2 nTPM
cerebral cortex: 8.2 nTPM
esophagus: 7.8 nTPM
tonsil: 7.4 nTPM
smooth muscle: 7 nTPM
skeletal muscle: 6.9 nTPM

Single-cell type

thymocytes: 313 nCPM
oligodendrocyte progenitor cells: 271 nCPM
megakaryocyte progenitors: 269 nCPM
somatotrophs: 261 nCPM
lactotrophs: 244 nCPM
megakaryocyte-erythroid progenitors: 244 nCPM

Immune cell

myeloid DC: 19 nTPM
NK-cell: 18 nTPM
non-classical monocyte: 13 nTPM
plasmacytoid DC: 13 nTPM
intermediate monocyte: 12 nTPM
total PBMC: 11 nTPM

Brain region

white matter: 19 nTPM
hypothalamus: 18 nTPM
pons: 18 nTPM
medulla oblongata: 18 nTPM
thalamus: 18 nTPM
cerebral cortex: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCFD2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 109 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Autism, susceptiblity to

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCFD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCFD2 as an antibody target. Whether an autoantibody or antibody against SCFD2 could matter depends on whether native SCFD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCFD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCFD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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