Seroatlas · Human Serome Atlas

GABPB1

GA-binding protein subunit beta-1

Also known as: E4TF1-47, GABP1_HUMAN, GABPB, GABPB2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q06547
Gene
GABPB1
Ensembl
ENSG00000104064
Chromosome
15
Canonical length
395 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytoplasmic bodies

OverviewNCBI Gene

This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q06547|GABPB1
     1  MSLVDLGKKL LEAARAGQDD EVRILMANGA PFTTDWLGTS PLHLAAQYGH YSTTEVLLRA
    61  GVSRDARTKV DRTPLHMAAS EGHASIVEVL LKHGADVNAK DMLKMTALHW ATEHNHQEVV
   121  ELLIKYGADV HTQSKFCKTA FDISIDNGNE DLAEILQIAM QNQINTNPES PDTVTIHAAT
   181  PQFIIGPGGV VNLTGLVSSE NSSKATDETG VSAVQFGNSS TSVLATLAAL AEASAPLSNS
   241  SETPVVATEE VVTAESVDGA IQQVVSSGGQ QVITIVTDGI QLGNLHSIPT SGIGQPIIVT
   301  MPDGQQVLTV PATDIAEETV ISEEPPAKRQ CIEIIENRVE SAEIEEREAL QKQLDEANRE
   361  AQKYRQQLLK KEQEAEAYRQ KLEAMTRLQT NKEAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GABPB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 33 nTPM
  • thymus: 23 nTPM
  • tonsil: 19 nTPM
  • lymph node: 18 nTPM
  • urinary bladder: 16 nTPM
  • testis: 15 nTPM

Single-cell type

  • mast cells: 346 nCPM
  • neutrophils: 276 nCPM
  • innate lymphoid cells: 189 nCPM
  • cardiomyocytes: 178 nCPM
  • hematopoietic stem cells: 144 nCPM
  • early spermatids: 126 nCPM

Immune cell

  • basophil: 45 nTPM
  • eosinophil: 33 nTPM
  • memory B-cell: 32 nTPM
  • T-reg: 28 nTPM
  • NK-cell: 27 nTPM
  • MAIT T-cell: 27 nTPM

Brain region

  • cerebellum: 31 nTPM
  • white matter: 26 nTPM
  • cerebral cortex: 23 nTPM
  • pons: 21 nTPM
  • medulla oblongata: 21 nTPM
  • thalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.91
gnomAD missense Z
2.93
DepMap mean gene effect
-0.65
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GABPB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GABPB1 as an antibody target. Whether an autoantibody or antibody against GABPB1 could matter depends on whether native GABPB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GABPB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GABPB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GABPB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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