DEDD

Protein identityUniProt · HPA

UniProt accession

O75618

Gene

DEDD

Ensembl

ENSG00000158796

Chromosome

1

Canonical length

318 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>O75618|DEDD
     1  MAGLKRRASQ VWPEEHGEQE HGLYSLHRMF DIVGTHLTHR DVRVLSFLFV DVIDDHERGL
    61  IRNGRDFLLA LERQGRCDES NFRQVLQLLR IITRHDLLPY VTLKRRRAVC PDLVDKYLEE
   121  TSIRYVTPRA LSDPEPRPPQ PSKTVPPHYP VVCCPTSGPQ MCSKRPARGR ATLGSQRKRR
   181  KSVTPDPKEK QTCDIRLRVR AEYCQHETAL QGNVFSNKQD PLERQFERFN QANTILKSRD
   241  LGSIICDIKF SELTYLDAFW RDYINGSLLE ALKGVFITDS LKQAVGHEAI KLLVNVDEED
   301  YELGRQKLLR NLMLQALP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEDD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

54 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.33

gnomAD pLI

0.96

gnomAD missense Z

2.21

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 21% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• decidualization
• extrinsic apoptotic signaling pathway via death domain receptors
• negative regulation of protein catabolic process
• negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
• regulation of apoptotic process
• spermatogenesis

Molecular functions

• DNA binding

Cellular components

• cytoplasm
• nucleolus

Protein domainsUniProt · Pfam · InterPro

• Death effector domain
• Death-like domain superfamily
• Death effector domain-containing protein
• TRADD-like N-terminal domain
• Death effector domain
• TRADD-like N-terminal domain

KeywordsUniProt

• Apoptosis
• Cytoplasm
• DNA-binding
• Nucleus
• Repressor
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of DEDD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CASP10
• CASP3
• CASP8
• FADD
• KRT18
• KRT8
• RYBP