PB1-like domain
IPR053793
Definition
The PB1 (Phox and Bem1) domain, comprising about 80 amino acid residues, is conserved among animals, fungi, amoebas, and plants. It functions as a protein binding module through PB1-mediated heterodimerization or homo-oligomerization [[cite:PMID:17726178], [cite:PMID:15590654], [cite:PMID:11483498], [cite:PMID:24706860]]. The PB1 domain is found in several signaling proteins including: - Mammalian MEK5, a MAP kinase kinase implicated in epidermal growth factor-induced cell proliferation. - Mammalian Sequestosome-1 (Sqstm1) or p62/ZIP, a protein linking the zeta isoform of protein kinase C to RIP and/or potassium channels. - Mammalian neutrophil cytosol factor 4 (NCF-4) or p40(phox), a cytosolic factor of the superoxide-generating NADPH oxidase in phagocytes. - Mammalian neutrophil cytosol factor 2 (NCF-2) or p67(phox), an oxidase activator. - Yeast bud emergence protein 1 (Bem1), necessary for cell polarization during vegetative growth. - Yeast cell division control protein 24 (CDC24), a guanine nucleotide exchange factor (GEF) for the small GTPase CDC42. - Plant AUXIN RESPONSE FACTOR (ARF) transcription factor family, regulates gene expression in response to auxin. The PB1 domains adopt an ubiquitin-like β-grasp fold, containing two α-helices and a mixed five-stranded β-sheet. PB1 domains may display an acidic surface (type I), a basic surface (tape II), or both surfaces (type I/II) on opposite faces of the domain structure to allow for front-to-back orientation of multiple PB1 domains [[cite:PMID:17726178], [cite:PMID:15590654], [cite:PMID:11483498], [cite:PMID:24706860]].
14 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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