Seroatlas · Human Serome Atlas

ADAP1

Arf-GAP with dual PH domain-containing protein 1

Also known as: ADAP1_HUMAN, CENTA1, GCS1L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75689
Gene: ADAP1
Ensembl: ENSG00000105963
Chromosome: 7
Canonical length: 374 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Enables GTPase activator activity. Predicted to be involved in cell surface receptor signaling pathway. Located in cytosol; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>O75689|ADAP1
     1  MAKERRRAVL ELLQRPGNAR CADCGAPDPD WASYTLGVFI CLSCSGIHRN IPQVSKVKSV
    61  RLDAWEEAQV EFMASHGNDA ARARFESKVP SFYYRPTPSD CQLLREQWIR AKYERQEFIY
   121  PEKQEPYSAG YREGFLWKRG RDNGQFLSRK FVLTEREGAL KYFNRNDAKE PKAVMKIEHL
   181  NATFQPAKIG HPHGLQVTYL KDNSTRNIFI YHEDGKEIVD WFNALRAARF HYLQVAFPGA
   241  GDADLVPKLS RNYLKEGYME KTGPKQTEGF RKRWFTMDDR RLMYFKDPLD AFARGEVFIG
   301  SKESGYTVLH GFPPSTQGHH WPHGITIVTP DRKFLFACET ESDQREWVAA FQKAVDRPML
   361  PQEYAVEAHF KHKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 131 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 131 nTPM
cerebral cortex: 127 nTPM
hippocampal formation: 124 nTPM
amygdala: 109 nTPM
midbrain: 86 nTPM
basal ganglia: 77 nTPM

Single-cell type

oocytes: 286 nCPM
colonocytes: 76 nCPM
oligodendrocytes: 60 nCPM
foveolar cells: 47 nCPM
enterocytes: 43 nCPM
monocytes: 42 nCPM

Immune cell

non-classical monocyte: 12 nTPM
intermediate monocyte: 7.3 nTPM
classical monocyte: 6.5 nTPM
gdT-cell: 6 nTPM
memory CD8 T-cell: 5.5 nTPM
myeloid DC: 5.1 nTPM

Brain region

white matter: 157 nTPM
cerebral cortex: 127 nTPM
medulla oblongata: 118 nTPM
midbrain: 116 nTPM
hippocampal formation: 108 nTPM
cerebellum: 104 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.53
gnomAD missense Z: 0.89
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAP1 as an antibody target. Whether an autoantibody or antibody against ADAP1 could matter depends on whether native ADAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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