Seroatlas · Human Serome Atlas

ZMYND11

Zinc finger MYND domain-containing protein 11

Also known as: BRAM1, BS69, ZMY11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15326
Gene: ZMYND11
Ensembl: ENSG00000015171
Chromosome: 10
Canonical length: 602 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homooligomer

OverviewNCBI Gene

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

602 residues, UniProt reviewed canonical sequence.

>Q15326|ZMYND11
     1  MARLTKRRQA DTKAIQHLWA AIEIIRNQKQ IANIDRITKY MSRVHGMHPK ETTRQLSLAV
    61  KDGLIVETLT VGCKGSKAGI EQEGYWLPGD EIDWETENHD WYCFECHLPG EVLICDLCFR
   121  VYHSKCLSDE FRLRDSSSPW QCPVCRSIKK KNTNKQEMGT YLRFIVSRMK ERAIDLNKKG
   181  KDNKHPMYRR LVHSAVDVPT IQEKVNEGKY RSYEEFKADA QLLLHNTVIF YGADSEQADI
   241  ARMLYKDTCH ELDELQLCKN CFYLSNARPD NWFCYPCIPN HELVWAKMKG FGFWPAKVMQ
   301  KEDNQVDVRF FGHHHQRAWI PSENIQDITV NIHRLHVKRS MGWKKACDEL ELHQRFLREG
   361  RFWKSKNEDR GEEEAESSIS STSNEQLKVT QEPRAKKGRR NQSVEPKKEE PEPETEAVSS
   421  SQEIPTMPQP IEKVSVSTQT KKLSASSPRM LHRSTQTTND GVCQSMCHDK YTKIFNDFKD
   481  RMKSDHKRET ERVVREALEK LRSEMEEEKR QAVNKAVANM QGEMDRKCKQ VKEKCKEEFV
   541  EEIKKLATQH KQLISQTKKK QWCYNCEEEA MYHCCWNTSY CSIKCQQEHW HAEHKRTCRR
   601  KR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMYND11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 93 nTPM
thyroid gland: 81 nTPM
spinal cord: 65 nTPM
tongue: 60 nTPM
skeletal muscle: 58 nTPM
blood vessel: 58 nTPM

Single-cell type

myonuclei: 233 nCPM
pituicytes/fscs: 221 nCPM
microglia: 219 nCPM
pituitary stem cells: 191 nCPM
distal convoluted tubule cells: 189 nCPM
renal connecting tubule cells: 187 nCPM

Immune cell

eosinophil: 19 nTPM
basophil: 16 nTPM
NK-cell: 15 nTPM
gdT-cell: 12 nTPM
memory CD8 T-cell: 12 nTPM
MAIT T-cell: 10 nTPM

Brain region

cerebellum: 89 nTPM
basal ganglia: 87 nTPM
white matter: 87 nTPM
cerebral cortex: 84 nTPM
thalamus: 82 nTPM
medulla oblongata: 81 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZMYND11.

Disease | AllUniProt

Conditions ZMYND11 is implicated in, by any mechanism.

Intellectual developmental disorder, autosomal dominant 30, with speech delay and behavioral abnormalities (MRD30) MIM:616083

Disease | GeneticClinVar

86 pathogenic / likely-pathogenic of 427 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability, autosomal dominant 30
Inborn genetic diseases
ZMYND11-related disorder
Global developmental delay
Neurodevelopmental disorder

Disease | ImmuneIEDB

Conditions an epitope on ZMYND11 was assayed in.

pancreatic ductal adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.12
gnomAD pLI: 1
gnomAD missense Z: 3.71
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

PWWP domain
Bromodomain
Zinc finger, PHD-type
Zinc finger, MYND-type
Zinc finger, FYVE/PHD-type
Zinc finger, RING/FYVE/PHD-type
Zinc finger, PHD-type, conserved site
Zinc finger, PHD-finger
Bromodomain-like superfamily
SAM domain-containing protein 1-like, WH domain
ZMYND11/ZMYD8, MYND zinc finger
Bromodomain
PWWP domain
SAM domain-containing protein 1, WH domain
ZMYND11/ZMYD8, MYND zinc finger
Zinc finger MYND domain-containing protein 11, PWWP domain
Zinc finger MYND domain-containing protein 11
ZMYND11, coiled-coil
ZMYND11 protein coiled-coil

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMYND11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMYND11 as an antibody target. Whether an autoantibody or antibody against ZMYND11 could matter depends on whether native ZMYND11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMYND11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMYND11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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