Seroatlas · Human Serome Atlas

CSRP2

Cysteine and glycine-rich protein 2

Also known as: CRP2, CSRP2_HUMAN, LMO5, SmLIM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16527
Gene: CSRP2
Ensembl: ENSG00000175183
Chromosome: 12
Canonical length: 193 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q16527|CSRP2
     1  MPVWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA IHDEEIYCKS
    61  CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESVQPHRP TTNPNTSKFA QKYGGAEKCS
   121  RCGDSVYAAE KIIGAGKPWH KNCFRCAKCG KSLESTTLTE KEGEIYCKGC YAKNFGPKGF
   181  GYGQGAGALV HAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSRP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 334 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 334 nTPM
esophagus: 96 nTPM
kidney: 90 nTPM
cervix: 80 nTPM
placenta: 79 nTPM
adipose tissue: 70 nTPM

Single-cell type

ocular epithelial cells: 1,187 nCPM
vascular smooth muscle cells: 542 nCPM
müller glia: 382 nCPM
esophageal basal cells: 355 nCPM
cytotrophoblasts: 331 nCPM
esophageal suprabasal cells: 280 nCPM

Immune cell

naive CD4 T-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
memory B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM

Brain region

hypothalamus: 40 nTPM
thalamus: 37 nTPM
white matter: 35 nTPM
medulla oblongata: 30 nTPM
cerebellum: 27 nTPM
midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSRP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSRP2 as an antibody target. Whether an autoantibody or antibody against CSRP2 could matter depends on whether native CSRP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSRP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSRP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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