UBP1

Protein identityUniProt · HPA

UniProt accession

Q9NZI7

Gene

UBP1

Ensembl

ENSG00000153560

Chromosome

3

Canonical length

540 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of viral transcription and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>Q9NZI7|UBP1
     1  MAWVLKMDEV IESGLVHDFD ASLSGIGQEL GAGAYSMSDV LALPIFKQED SSLPLDGETE
    61  HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR KMGDMPEING KLVKSIIRVV
   121  FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT
   181  SAFIQVHCIS TEFTPRKHGG EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA
   241  DRKQKTDREK MEKRTAHEKE KYQPSYDTTI LTEMRLEPII EDAVEHEQKK SSKRTLPADY
   301  GDSLAKRGSC SPWPDAPTAY VNNSPSPAPT FTSPQQSTCS VPDSNSSSPN HQGDGASQTS
   361  GEQIQPSATI QETQQWLLKN RFSSYTRLFS NFSGADLLKL TKEDLVQICG AADGIRLYNS
   421  LKSRSVRPRL TIYVCREQPS STVLQGQQQA ASSASENGSG APYVYHAIYL EEMIASEVAR
   481  KLALVFNIPL HQINQVYRQG PTGIHILVSD QMVQNFQDES CFLFSTVKAE SSDGIHIILK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

41 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.09

gnomAD pLI

1

gnomAD missense Z

2.99

DepMap mean gene effect

0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• negative regulation of viral transcription
• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• cytosol
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• CP2 transcription factor
• Sterile alpha motif/pointed domain superfamily
• Transcription factor CP2-like
• SAM domain
• GRHL1/CP2, C-terminal domain
• CP2 transcription factor
• SAM domain (Sterile alpha motif)
• GRHL1-like, C-terminal domain
• Upstream-binding protein 1, SAM domain

KeywordsUniProt

• DNA-binding
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of UBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PIAS1
• TFCP2