PLAG1
Zinc finger protein PLAG1
Also known as: PLAG1_HUMAN, ZNF912
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6DJT9
- Gene
- PLAG1
- Ensembl
- ENSG00000181690
- Chromosome
- 8
- Canonical length
- 500 aa
- Protein class
- Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nuclear speckles,Centrosome,Cytosol
OverviewNCBI Gene
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
500 residues, UniProt reviewed canonical sequence.
>Q6DJT9|PLAG1
1 MATVIPGDLS EVRDTQKVPS GKRKRGETKP RKNFPCQLCD KAFNSVEKLK VHSYSHTGER
61 PYKCIQQDCT KAFVSKYKLQ RHMATHSPEK THKCNYCEKM FHRKDHLKNH LHTHDPNKET
121 FKCEECGKNY NTKLGFKRHL ALHAATSGDL TCKVCLQTFE STGVLLEHLK SHAGKSSGGV
181 KEKKHQCEHC DRRFYTRKDV RRHMVVHTGR KDFLCQYCAQ RFGRKDHLTR HMKKSHNQEL
241 LKVKTEPVDF LDPFTCNVSV PIKDELLPVM SLPSSELLSK PFTNTLQLNL YNTPFQSMQS
301 SGSAHQMITT LPLGMTCPID MDTVHPSHHL SFKYPFSSTS YAISIPEKEQ PLKGEIESYL
361 MELQGGVPSS SQDSQASSSS KLGLDPQIGS LDDGAGDLSL SKSSISISDP LNTPALDFSQ
421 LFNFIPLNGP PYNPLSVGSL GMSYSQEEAH SSVSQLPPQT QDLQDPANTI GLGSLHSLSA
481 AFTSSLSTST TLPRFHQAFQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PLAG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.58
- Highest tissue expression
- 7.2 nTPM
Expression across tissuesHPA
Tissue
- retina: 7.2 nTPM
- epididymis: 3.9 nTPM
- pituitary gland: 3.6 nTPM
- fallopian tube: 2.9 nTPM
- heart muscle: 2.9 nTPM
- salivary gland: 2.9 nTPM
Single-cell type
- corticotrophs: 129 nCPM
- adrenal medulla cells: 128 nCPM
- microglia: 125 nCPM
- pituitary stem cells: 117 nCPM
- lactotrophs: 106 nCPM
- thyrotrophs: 88 nCPM
Immune cell
- naive CD4 T-cell: 1.8 nTPM
- naive CD8 T-cell: 1.8 nTPM
- memory B-cell: 1.3 nTPM
- naive B-cell: 0.7 nTPM
- basophil: 0.5 nTPM
- eosinophil: 0.4 nTPM
Brain region
- cerebellum: 5.6 nTPM
- white matter: 4.5 nTPM
- pons: 4.3 nTPM
- medulla oblongata: 3.6 nTPM
- midbrain: 3.5 nTPM
- thalamus: 3.2 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about PLAG1.
Disease | AllUniProt
Conditions PLAG1 is implicated in, by any mechanism.
- Silver-Russell syndrome 4 (SRS4) MIM:618907
Disease | GeneticClinVar
11 pathogenic / likely-pathogenic of 85 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Silver-russell syndrome 4
- Silver-Russell syndrome 1
- Intellectual disability
- PLAG1-related disorder
- Russell-Silver syndrome
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.19
- gnomAD pLI
- 1
- gnomAD missense Z
- 2.25
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- gland morphogenesis
- multicellular organism growth
- negative regulation of gene expression
- positive regulation of gene expression
- positive regulation of glial cell proliferation
- positive regulation of transcription by RNA polymerase II
- prostate gland growth
- regulation of DNA-templated transcription
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PLAG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PLAG1 as an antibody target. Whether an autoantibody or antibody against PLAG1 could matter depends on whether native PLAG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PLAG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PLAG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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