Seroatlas · Human Serome Atlas

KLF8

Krueppel-like factor 8

Also known as: BKLF3, DXS741, KLF8_HUMAN, ZNF741

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95600
Gene: KLF8
Ensembl: ENSG00000102349
Chromosome: X
Canonical length: 359 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>O95600|KLF8
     1  MVDMDKLINN LEVQLNSEGG SMQVFKQVTA SVRNRDPPEI EYRSNMTSPT LLDANPMENP
    61  ALFNDIKIEP PEELLASDFS LPQVEPVDLS FHKPKAPLQP ASMLQAPIRP PKPQSSPQTL
   121  VVSTSTSDMS TSANIPTVLT PGSVLTSSQS TGSQQILHVI HTIPSVSLPN KMGGLKTIPV
   181  VVQSLPMVYT TLPADGGPAA ITVPLIGGDG KNAGSVKVDP TSMSPLEIPS DSEESTIESG
   241  SSALQSLQGL QQEPAAMAQM QGEESLDLKR RRIHQCDFAG CSKVYTKSSH LKAHRRIHTG
   301  EKPYKCTWDG CSWKFARSDE LTRHFRKHTG IKPFRCTDCN RSFSRSDHLS LHRRRHDTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLF8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

skin: 16 nTPM
esophagus: 12 nTPM
blood vessel: 9.7 nTPM
vagina: 9.5 nTPM
adipose tissue: 8.5 nTPM
cervix: 8.3 nTPM

Single-cell type

esophageal apical cells: 124 nCPM
leydig cells: 78 nCPM
esophageal suprabasal cells: 73 nCPM
adipocytes: 58 nCPM
sertoli cells: 53 nCPM
peritubular myoid cells: 49 nCPM

Immune cell

NK-cell: 1.5 nTPM
memory B-cell: 1.2 nTPM
naive B-cell: 1.2 nTPM
myeloid DC: 0.6 nTPM
memory CD8 T-cell: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM

Brain region

basal ganglia: 5.8 nTPM
cerebellum: 5.2 nTPM
cerebral cortex: 4.8 nTPM
amygdala: 3.9 nTPM
hypothalamus: 3.9 nTPM
white matter: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLF8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLF8 as an antibody target. Whether an autoantibody or antibody against KLF8 could matter depends on whether native KLF8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLF8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLF8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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