TMEM97
Sigma intracellular receptor 2
Also known as: Ã2R, MAC30, SGMR2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5BJF2
- Gene
- TMEM97
- Ensembl
- ENSG00000109084
- Chromosome
- 17
- Canonical length
- 176 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Endoplasmic reticulum
- Quaternary structure
- Homodimer
OverviewNCBI Gene
TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009]
Canonical amino-acid sequenceUniProt
176 residues, UniProt reviewed canonical sequence.
>Q5BJF2|TMEM97
1 MGAPATRRCV EWLLGLYFLS HIPITLFMDL QAVLPRELYP VEFRNLLKWY AKEFKDPLLQ
61 EPPAWFKSFL FCELVFQLPF FPIATYAFLK GSCKWIRTPA IIYSVHTMTT LIPILSTFLF
121 EDFSKASGFK GQRPETLHER LTLVSVYAPY LLIPFILLIF MLRSPYYKYE EKRKKKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM97 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 303 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 303 nTPM
- liver: 106 nTPM
- testis: 54 nTPM
- stomach: 38 nTPM
- urinary bladder: 25 nTPM
- adrenal gland: 24 nTPM
Single-cell type
- oocytes: 332 nCPM
- gastric chief cells: 281 nCPM
- urothelial cells: 231 nCPM
- pancreatic acinar cells: 172 nCPM
- mucous neck cells: 171 nCPM
- gastric progenitor cells: 154 nCPM
Immune cell
- myeloid DC: 16 nTPM
- memory B-cell: 11 nTPM
- naive CD4 T-cell: 10 nTPM
- naive CD8 T-cell: 9.8 nTPM
- NK-cell: 9.5 nTPM
- memory CD8 T-cell: 9.4 nTPM
Brain region
- pons: 40 nTPM
- midbrain: 38 nTPM
- medulla oblongata: 28 nTPM
- cerebral cortex: 26 nTPM
- thalamus: 23 nTPM
- white matter: 21 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.5
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.17
- DepMap mean gene effect
- -0.22
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cholesterol homeostasis
- positive regulation of lipoprotein transport
- positive regulation of wound healing
- regulation of cell growth
- regulation of intracellular cholesterol transport
- regulation of intracellular lipid transport
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- EXPERA domain
- EXPERA (EXPanded EBP superfamily)
- Sigma intracellular receptor 2
- Sigma-2 receptor-like
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TMEM97 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM97 as an antibody target. Whether an autoantibody or antibody against TMEM97 could matter depends on whether native TMEM97 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM97 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM97 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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