SPCS2
Signal peptidase complex subunit 2
Also known as: KIAA0102, SPCS2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15005
- Gene
- SPCS2
- Ensembl
- ENSG00000118363
- Chromosome
- 11
- Canonical length
- 226 aa
- Protein class
- Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
Predicted to enable peptidase activity. Involved in signal peptide processing. Located in endoplasmic reticulum membrane. Part of signal peptidase complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
226 residues, UniProt reviewed canonical sequence.
>Q15005|SPCS2
1 MAAAAVQGGR SGGSGGCSGA GGASNCGTGS GRSGLLDKWK IDDKPVKIDK WDGSAVKNSL
61 DDSAKKVLLE KYKYVENFGL IDGRLTICTI SCFFAIVALI WDYMHPFPES KPVLALCVIS
121 YFVMMGILTI YTSYKEKSIF LVAHRKDPTG MDPDDIWQLS SSLKRFDDKY TLKLTFISGR
181 TKQQREAEFT KSIAKFFDHS GTLVMDAYEP EISRLHDSLA IERKIKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPCS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 208 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 208 nTPM
- tonsil: 145 nTPM
- liver: 142 nTPM
- parathyroid gland: 139 nTPM
- thyroid gland: 135 nTPM
- salivary gland: 131 nTPM
Single-cell type
- plasma cells: 1,131 nCPM
- epididymal principal cells: 617 nCPM
- gastric progenitor cells: 587 nCPM
- parietal cells: 467 nCPM
- syncytiotrophoblasts: 448 nCPM
- gastric chief cells: 415 nCPM
Immune cell
- basophil: 555 nTPM
- plasmacytoid DC: 471 nTPM
- total PBMC: 438 nTPM
- memory B-cell: 409 nTPM
- naive B-cell: 355 nTPM
- MAIT T-cell: 322 nTPM
Brain region
- white matter: 120 nTPM
- hypothalamus: 115 nTPM
- medulla oblongata: 108 nTPM
- spinal cord: 107 nTPM
- cerebellum: 105 nTPM
- pons: 100 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.36
- gnomAD pLI
- 0.93
- gnomAD missense Z
- 1.42
- DepMap mean gene effect
- -0.71
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Signal peptidase complex subunit 2
- Microsomal signal peptidase 25 kDa subunit (SPC25)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SPCS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPCS2 as an antibody target. Whether an autoantibody or antibody against SPCS2 could matter depends on whether native SPCS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPCS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPCS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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