Seroatlas · Human Serome Atlas

VIRMA

Protein virilizer homolog

Also known as: DKFZP434I116, fSAP121, KIAA1429, VIR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q69YN4
Gene: VIRMA
Ensembl: ENSG00000164944
Chromosome: 8
Canonical length: 1812 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables RNA binding activity. Involved in mRNA processing. Located in RNA N6-methyladenosine methyltransferase complex; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1812 residues, UniProt reviewed canonical sequence.

>Q69YN4|VIRMA
     1  MAVDSAMELL FLDTFKHPSA EQSSHIDVVR FPCVVYINEV RVIPPGVRAH SSLPDNRAYG
    61  ETSPHTFQLD LFFNNVSKPS APVFDRLGSL EYDENTSIIF RPNSKVNTDG LVLRGWYNCL
   121  TLAIYGSVDR VISHDRDSPP PPPPPPPPPQ PQPSLKRNPK HADGEKEDQF NGSPPRPQPR
   181  GPRTPPGPPP PDDDEDDPVP LPVSGDKEED APHREDYFEP ISPDRNSVPQ EGQYSDEGEV
   241  EEEQQEEGEE DEDDVDVEEE EDEDEDDRRT VDSIPEEEEE DEEEEGEEDE EGEGDDGYEQ
   301  ISSDEDGIAD LERETFKYPN FDVEYTAEDL ASVPPMTYDP YDRELVPLLY FSCPYKTTFE
   361  IEISRMKDQG PDKENSGAIE ASVKLTELLD LYREDRGAKW VTALEEIPSL IIKGLSYLQL
   421  KNTKQDSLGQ LVDWTMQALN LQVALRQPIA LNVRQLKAGT KLVSSLAECG AQGVTGLLQA
   481  GVISGLFELL FADHVSSSLK LNAFKALDSV ISMTEGMEAF LRGRQNEKSG YQKLLELILL
   541  DQTVRVVTAG SAILQKCHFY EVLSEIKRLG DHLAEKTSSL PNHSEPDHDT DAGLERTNPE
   601  YENEVEASMD MDLLESSNIS EGEIERLINL LEEVFHLMET APHTMIQQPV KSFPTMARIT
   661  GPPERDDPYP VLFRYLHSHH FLELVTLLLS IPVTSAHPGV LQATKDVLKF LAQSQKGLLF
   721  FMSEYEATNL LIRALCHFYD QDEEEGLQSD GVIDDAFALW LQDSTQTLQC ITELFSHFQR
   781  CTASEETDHS DLLGTLHNLY LITFNPVGRS AVGHVFSLEK NLQSLITLME YYSKEALGDS
   841  KSKKSVAYNY ACILILVVVQ SSSDVQMLEQ HAASLLKLCK ADENNAKLQE LGKWLEPLKN
   901  LRFEINCIPN LIEYVKQNID NLMTPEGVGL TTALRVLCNV ACPPPPVEGQ QKDLKWNLAV
   961  IQLFSAEGMD TFIRVLQKLN SILTQPWRLH VNMGTTLHRV TTISMARCTL TLLKTMLTEL
  1021  LRGGSFEFKD MRVPSALVTL HMLLCSIPLS GRLDSDEQKI QNDIIDILLT FTQGVNEKLT
  1081  ISEETLANNT WSLMLKEVLS SILKVPEGFF SGLILLSELL PLPLPMQTTQ VIEPHDISVA
  1141  LNTRKLWSMH LHVQAKLLQE IVRSFSGTTC QPIQHMLRRI CVQLCDLASP TALLIMRTVL
  1201  DLIVEDLQST SEDKEKQYTS QTTRLLALLD ALASHKACKL AILHLINGTI KGDERYAEIF
  1261  QDLLALVRSP GDSVIRQQCV EYVTSILQSL CDQDIALILP SSSEGSISEL EQLSNSLPNK
  1321  ELMTSICDCL LATLANSESS YNCLLTCVRT MMFLAEHDYG LFHLKSSLRK NSSALHSLLK
  1381  RVVSTFSKDT GELASSFLEF MRQILNSDTI GCCGDDNGLM EVEGAHTSRT MSINAAELKQ
  1441  LLQSKEESPE NLFLELEKLV LEHSKDDDNL DSLLDSVVGL KQMLESSGDP LPLSDQDVEP
  1501  VLSAPESLQN LFNNRTAYVL ADVMDDQLKS MWFTPFQAEE IDTDLDLVKV DLIELSEKCC
  1561  SDFDLHSELE RSFLSEPSSP GRTKTTKGFK LGKHKHETFI TSSGKSEYIE PAKRAHVVPP
  1621  PRGRGRGGFG QGIRPHDIFR QRKQNTSRPP SMHVDDFVAA ESKEVVPQDG IPPPKRPLKV
  1681  SQKISSRGGF SGNRGGRGAF HSQNRFFTPP ASKGNYSRRE GTRGSSWSAQ NTPRGNYNES
  1741  RGGQSNFNRG PLPPLRPLSS TGYRPSPRDR ASRGRGGLGP SWASANSGSG GSRGKFVSGG
  1801  SGRGRHVRSF TR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VIRMA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 26 nTPM
thymus: 19 nTPM
breast: 16 nTPM
testis: 16 nTPM
ovary: 15 nTPM
tonsil: 14 nTPM

Single-cell type

early primary spermatocytes: 137 nCPM
myonuclei: 131 nCPM
differentiating spermatogonia: 88 nCPM
neutrophil progenitors: 81 nCPM
erythrocyte progenitors: 81 nCPM
somatotrophs: 78 nCPM

Immune cell

basophil: 14 nTPM
non-classical monocyte: 14 nTPM
MAIT T-cell: 11 nTPM
NK-cell: 9.5 nTPM
memory CD8 T-cell: 9.1 nTPM
naive CD4 T-cell: 9.1 nTPM

Brain region

cerebellum: 28 nTPM
white matter: 23 nTPM
basal ganglia: 22 nTPM
hypothalamus: 20 nTPM
spinal cord: 20 nTPM
thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
DepMap mean gene effect: -1.26
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-type fold
Protein virilizer
Virilizer, N-terminal
Virilizer, N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VIRMA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VIRMA as an antibody target. Whether an autoantibody or antibody against VIRMA could matter depends on whether native VIRMA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VIRMA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VIRMA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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