Seroatlas · Human Serome Atlas

LCLAT1

Lysocardiolipin acyltransferase 1

Also known as: AGPAT8, ALCAT1, FLJ37965, LCLT1_HUMAN, LPLAT6, LYCAT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UWP7
Gene
LCLAT1
Ensembl
ENSG00000172954
Chromosome
2
Canonical length
414 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>Q6UWP7|LCLAT1
     1  MHSRGREIVV LLNPWSINEA VSSYCTYFIK QDSKSFGIMV SWKGIYFILT LFWGSFFGSI
    61  FMLSPFLPLM FVNPSWYRWI NNRLVATWLT LPVALLETMF GVKVIITGDA FVPGERSVII
   121  MNHRTRMDWM FLWNCLMRYS YLRLEKICLK ASLKGVPGFG WAMQAAAYIF IHRKWKDDKS
   181  HFEDMIDYFC DIHEPLQLLI FPEGTDLTEN SKSRSNAFAE KNGLQKYEYV LHPRTTGFTF
   241  VVDRLREGKN LDAVHDITVA YPHNIPQSEK HLLQGDFPRE IHFHVHRYPI DTLPTSKEDL
   301  QLWCHKRWEE KEERLRSFYQ GEKNFYFTGQ SVIPPCKSEL RVLVVKLLSI LYWTLFSPAM
   361  CLLIYLYSLV KWYFIITIVI FVLQERIFGG LEIIELACYR LLHKQPHLNS KKNE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCLAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 11 nTPM
  • heart muscle: 11 nTPM
  • thyroid gland: 10 nTPM
  • epididymis: 9.1 nTPM
  • kidney: 8.8 nTPM
  • small intestine: 8.7 nTPM

Single-cell type

  • cardiomyocytes: 322 nCPM
  • lactotrophs: 208 nCPM
  • proximal tubule cells: 206 nCPM
  • cone photoreceptor cells: 172 nCPM
  • respiratory ciliated cells: 161 nCPM
  • choroid plexus epithelial cells: 160 nCPM

Immune cell

  • basophil: 16 nTPM
  • naive CD4 T-cell: 12 nTPM
  • naive CD8 T-cell: 11 nTPM
  • naive B-cell: 9.7 nTPM
  • memory CD4 T-cell: 8.2 nTPM
  • memory B-cell: 7.4 nTPM

Brain region

  • cerebellum: 70 nTPM
  • white matter: 69 nTPM
  • cerebral cortex: 67 nTPM
  • hypothalamus: 66 nTPM
  • basal ganglia: 61 nTPM
  • hippocampal formation: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
0.92
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LCLAT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCLAT1 as an antibody target. Whether an autoantibody or antibody against LCLAT1 could matter depends on whether native LCLAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCLAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LCLAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LCLAT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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