Seroatlas · Human Serome Atlas

CIAO1

Probable cytosolic iron-sulfur protein assembly protein CIAO1

Also known as: CIA1, CIAO1_HUMAN, WDR39

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O76071
Gene
CIAO1
Ensembl
ENSG00000144021
Chromosome
2
Canonical length
339 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Involved in protein maturation. Located in cytoplasm. Part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>O76071|CIAO1
     1  MKDSLVLLGR VPAHPDSRCW FLAWNPAGTL LASCGGDRRI RIWGTEGDSW ICKSVLSEGH
    61  QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL
   121  ATCSRDKSVW VWEVDEEDEY ECVSVLNSHT QDVKHVVWHP SQELLASASY DDTVKLYREE
   181  EDDWVCCATL EGHESTVWSL AFDPSGQRLA SCSDDRTVRI WRQYLPGNEQ GVACSGSDPS
   241  WKCICTLSGF HSRTIYDIAW CQLTGALATA CGDDAIRVFQ EDPNSDPQQP TFSLTAHLHQ
   301  AHSQDVNCVA WNPKEPGLLA SCSDDGEVAF WKYQRPEGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIAO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 34 nTPM
  • liver: 31 nTPM
  • adrenal gland: 30 nTPM
  • basal ganglia: 30 nTPM
  • cerebral cortex: 29 nTPM
  • skeletal muscle: 29 nTPM

Single-cell type

  • tuft cells: 115 nCPM
  • cytotrophoblasts: 105 nCPM
  • esophageal basal cells: 97 nCPM
  • migrating cytotrophoblasts: 93 nCPM
  • extravillous trophoblasts: 87 nCPM
  • esophageal apical cells: 85 nCPM

Immune cell

  • eosinophil: 34 nTPM
  • non-classical monocyte: 34 nTPM
  • total PBMC: 33 nTPM
  • MAIT T-cell: 32 nTPM
  • basophil: 30 nTPM
  • NK-cell: 30 nTPM

Brain region

  • cerebellum: 39 nTPM
  • white matter: 38 nTPM
  • cerebral cortex: 37 nTPM
  • spinal cord: 37 nTPM
  • thalamus: 36 nTPM
  • pons: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CIAO1.

Disease | AllUniProt

Conditions CIAO1 is implicated in, by any mechanism.

  • Multiple mitochondrial dysfunctions syndrome 10 (MMDS10) MIM:620960

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 61 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0
gnomAD missense Z
1.12
DepMap mean gene effect
-1.21
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIAO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIAO1 as an antibody target. Whether an autoantibody or antibody against CIAO1 could matter depends on whether native CIAO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIAO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIAO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CIAO1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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