Seroatlas · Human Serome Atlas

SLC35B1

Solute carrier family 35 member B1

Also known as: AXER, S35B1_HUMAN, UGTREL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P78383
Gene
SLC35B1
Ensembl
ENSG00000121073
Chromosome
17
Canonical length
322 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Endoplasmic reticulum,Vesicles

OverviewNCBI Gene

This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>P78383|SLC35B1
     1  MASSSSLVPD RLRLPLCFLG VFVCYFYYGI LQEKITRGKY GEGAKQETFT FALTLVFIQC
    61  VINAVFAKIL IQFFDTARVD RTRSWLYAAC SISYLGAMVS SNSALQFVNY PTQVLGKSCK
   121  PIPVMLLGVT LLKKKYPLAK YLCVLLIVAG VALFMYKPKK VVGIEEHTVG YGELLLLLSL
   181  TLDGLTGVSQ DHMRAHYQTG SNHMMLNINL WSTLLLGMGI LFTGELWEFL SFAERYPAII
   241  YNILLFGLTS ALGQSFIFMT VVYFGPLTCS IITTTRKFFT ILASVILFAN PISPMQWVGT
   301  VLVFLGLGLD AKFGKGAKKT SH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 62 nTPM
  • tongue: 56 nTPM
  • epididymis: 50 nTPM
  • liver: 43 nTPM
  • choroid plexus: 35 nTPM
  • thyroid gland: 34 nTPM

Single-cell type

  • extravillous trophoblasts: 158 nCPM
  • epididymal principal cells: 156 nCPM
  • plasma cells: 139 nCPM
  • enterocytes: 129 nCPM
  • esophageal apical cells: 106 nCPM
  • syncytiotrophoblasts: 94 nCPM

Immune cell

  • plasmacytoid DC: 43 nTPM
  • myeloid DC: 32 nTPM
  • intermediate monocyte: 28 nTPM
  • classical monocyte: 27 nTPM
  • basophil: 25 nTPM
  • non-classical monocyte: 19 nTPM

Brain region

  • choroid plexus: 24 nTPM
  • hypothalamus: 21 nTPM
  • thalamus: 17 nTPM
  • cerebral cortex: 17 nTPM
  • midbrain: 16 nTPM
  • medulla oblongata: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
0.79
DepMap mean gene effect
-1.25
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC35B1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35B1 as an antibody target. Whether an autoantibody or antibody against SLC35B1 could matter depends on whether native SLC35B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35B1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC35B1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...