CYP1A1

Protein identityUniProt · HPA

UniProt accession

P04798

Gene

CYP1A1

Ensembl

ENSG00000140465

Chromosome

15

Canonical length

512 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>P04798|CYP1A1
     1  MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG HMLTLGKNPH
    61  LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG DDFKGRPDLY TFTLISNGQS
   121  MSFSPDSGPV WAARRRLAQN GLKSFSIASD PASSTSCYLE EHVSKEAEVL ISTLQELMAG
   181  PGHFNPYRYV VVSVTNVICA ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL
   241  RYLPNPSLNA FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV
   301  QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV IGRSRRPRLS
   361  DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY IPKGRCVFVN QWQINHDQKL
   421  WVNPSEFLPE RFLTPDGAID KVLSEKVIIF GMGKRKCIGE TIARWEVFLF LAILLQRVEF
   481  SVPLGVKVDM TPIYGLTMKH ACCEHFQMQL RS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYP1A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

62 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.78

gnomAD pLI

0

gnomAD missense Z

-0.36

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 9-cis-retinoic acid biosynthetic process
• amine metabolic process
• camera-type eye development
• cellular response to copper ion
• coumarin metabolic process
• digestive tract development
• epoxygenase P450 pathway
• estrogen metabolic process
• fatty acid metabolic process
• flavonoid metabolic process
• hepatocyte differentiation
• hydrogen peroxide biosynthetic process
• lipid hydroxylation
• long-chain fatty acid biosynthetic process
• long-chain fatty acid metabolic process
• maternal process involved in parturition
• nitric oxide metabolic process
• omega-hydroxylase P450 pathway
• phenol-containing compound metabolic process
• porphyrin-containing compound metabolic process
• positive regulation of G1/S transition of mitotic cell cycle
• response to 2,3,7,8-tetrachlorodibenzodioxine
• response to 3-methylcholanthrene
• response to Aroclor 1254
• response to arsenic-containing substance
• response to food
• response to genistein
• response to herbicide
• response to hyperoxia
• response to hypoxia
• response to immobilization stress
• response to iron(III) ion
• response to lipopolysaccharide
• response to nematode
• response to vitamin A
• retinol metabolic process
• steroid biosynthetic process
• steroid catabolic process
• steroid metabolic process
• tissue remodeling
• toxin metabolic process
• vitamin D metabolic process
• xenobiotic catabolic process
• xenobiotic metabolic process
• dibenzo-p-dioxin catabolic process
• ethylene metabolic process
• insecticide metabolic process
• response to diphenyl ether

Molecular functions

• arachidonate monooxygenase activity
• demethylase activity
• enzyme binding
• estrogen 16-alpha-hydroxylase activity
• estrogen 2-hydroxylase activity
• heme binding
• Hsp70 protein binding
• Hsp90 protein binding
• hydroperoxy icosatetraenoate dehydratase activity
• iron ion binding
• long-chain fatty acid omega-1 hydroxylase activity
• long-chain fatty acid omega-hydroxylase activity
• monooxygenase activity
• oxidoreductase activity
• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
• oxygen binding
• steroid hydroxylase activity
• vitamin D 24-hydroxylase activity
• flavonoid 3'-monooxygenase activity
• oxidoreductase activity, acting on diphenols and related substances as donors

Cellular components

• endoplasmic reticulum membrane
• mitochondrial inner membrane
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Cytochrome P450
• Cytochrome P450, E-class, group I
• Cytochrome P450, E-class, group I, CYP1
• Cytochrome P450, conserved site
• Cytochrome P450 superfamily
• Cytochrome P450

KeywordsUniProt

• Cytoplasm
• Endoplasmic reticulum
• Fatty acid metabolism
• Glycoprotein
• Heme
• Iron
• Lipid biosynthesis
• Lipid metabolism
• Lyase
• Membrane
• Metal-binding
• Microsome
• Mitochondrion
• Mitochondrion inner membrane
• Monooxygenase
• Oxidoreductase
• Steroid biosynthesis

InteractionsUniProt · HPA

Protein binding partners of CYP1A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HSP90
• PGRMC1