Seroatlas · Human Serome Atlas

TEX10

Testis-expressed protein 10

Also known as: bA208F1.2, FLJ20287, Ipi1, TEX10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NXF1
Gene
TEX10
Ensembl
ENSG00000136891
Chromosome
9
Canonical length
929 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

Located in mitochondrion and nucleoplasm. Part of MLL1 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

929 residues, UniProt reviewed canonical sequence.

>Q9NXF1|TEX10
     1  MTKKRKRQHD FQKVKLKVGK KKPKLQNATP TNFKTKTIHL PEQLKEDGTL PTNNRKLNIK
    61  DLLSQMHHYN AGVKQSALLG LKDLLSQYPF IIDAHLSNIL SEVTAVFTDK DANVRLAAVQ
   121  LLQFLAPKIR AEQISPFFPL VSAHLSSAMT HITEGIQEDS LKVLDILLEQ YPALITGRSS
   181  ILLKNFVELI SHQQLSKGLI NRDRSQSWIL SVNPNRRLTS QQWRLKVLVR LSKFLQALAD
   241  GSSRLRESEG LQEQKENPHA TSNSIFINWK EHANDQQHIQ VYENGGSQPN VSSQFRLRYL
   301  VGGLSGVDEG LSSTENLKGF IEIIIPLLIE CWVEAVPPQL ATPVGNGIER EPLQVMQQVL
   361  NIISLLWKLS KQQDETHKLE SWLRKNYLID FKHHFMSRFP YVLKEITKHK RKEPNKSIKH
   421  CTVLSNNIDH LLLNLTLSDI MVSLANASTL QKDCSWIEMI RKFVTETLED GSRLNSKQLN
   481  RLLGVSWRLM QIQPNREDTE TLIKAVYTLY QQRGLILPVR TLLLKFFSKI YQTEELRSCR
   541  FRYRSKVLSR WLAGLPLQLA HLGSRNPELS TQLIDIIHTA AARANKELLK SLQATALRIY
   601  DPQEGAVVVL PADSQQRLVQ LVYFLPSLPA DLLSRLSRCC IMGRLSSSLA AMLIGILHMR
   661  SSFSGWKYSA KDWLMSDVDY FSFLFSTLTG FSKEELTWLQ SLRGVPHVIQ TQLSPVLLYL
   721  TDLDQFLHHW DVTEAVFHSL LVIPARSQNF DILQSAISKH LVGLTVIPDS TAGCVFGVIC
   781  KLLDHTCVVS ETLLPFLASC CYSLLYFLLT IEKGEAEHLR KRDKLWGVCV SILALLPRVL
   841  RLMLQSLRVN RVGPEELPVV GQLLRLLLQH APLRTHMLTN AILVQQIIKN ITTLKSGSVQ
   901  EQWLTDLHYC FNVYITGHPQ GPSALATVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • testis: 21 nTPM
  • thymus: 21 nTPM
  • placenta: 18 nTPM
  • skeletal muscle: 15 nTPM
  • lymph node: 13 nTPM
  • tonsil: 13 nTPM

Single-cell type

  • epicardial cells: 196 nCPM
  • cardiomyocytes: 137 nCPM
  • cytotrophoblasts: 107 nCPM
  • syncytiotrophoblasts: 87 nCPM
  • migrating cytotrophoblasts: 74 nCPM
  • basal keratinocytes: 62 nCPM

Immune cell

  • basophil: 18 nTPM
  • naive B-cell: 13 nTPM
  • memory B-cell: 12 nTPM
  • naive CD8 T-cell: 12 nTPM
  • T-reg: 12 nTPM
  • NK-cell: 11 nTPM

Brain region

  • cerebellum: 16 nTPM
  • white matter: 13 nTPM
  • choroid plexus: 12 nTPM
  • hypothalamus: 12 nTPM
  • cerebral cortex: 11 nTPM
  • basal ganglia: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
1.54
DepMap mean gene effect
-0.79
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEX10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX10 as an antibody target. Whether an autoantibody or antibody against TEX10 could matter depends on whether native TEX10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEX10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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