Seroatlas · Human Serome Atlas

NEPRO

Nucleolus and neural progenitor protein

Also known as: C3orf17, DKFZP434F2021, NEPRO_HUMAN, NET17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NW34
Gene
NEPRO
Ensembl
ENSG00000163608
Chromosome
3
Canonical length
567 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to be involved in negative regulation of neuron differentiation and positive regulation of Notch signaling pathway. Predicted to be located in nucleolus. Predicted to be active in nucleus. Implicated in anauxetic dysplasia 3. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

567 residues, UniProt reviewed canonical sequence.

>Q6NW34|NEPRO
     1  MMAAVPPGLE PWNRVRIPKA GNRSAVTVQN PGAALDLCIA AVIKECHLVI LSLKSQTLDA
    61  ETDVLCAVLY SNHNRMGRHK PHLALKQVEQ CLKRLKNMNL EGSIQDLFEL FSSNENQPLT
   121  TKVCVVPSQP VVELVLMKVL GACKLLLRLL DCCCKTFLLT VKHLGLQEFI ILNLVMVGLV
   181  SRLWVLYKGV LKRLILLYEP LFGLLQEVAR IQPMPYFKDF TFPSDITEFL GQPYFEAFKK
   241  KMPIAFAAKG INKLLNKLFL INEQSPRASE ETLLGISKKA KQMKINVQNN VDLGQPVKNK
   301  RVFKEESSEF DVRAFCNQLK HKATQETSFD FKCSQSRLKT TKYSSQKVIG TPHAKSFVQR
   361  FREAESFTQL SEEIQMAVVW CRSKKLKAQA IFLGNKLLKS NRLKHLEAQG TSLPKKLECI
   421  KTSICNHLLR GSGIKTSKHH LRQRRSQNKF LRRQRKPQRK LQSTLLREIQ QFSQGTRKSA
   481  TDTSAKWRLS HCTVHRTDLY PNSKQLLNSG VSMPVIQTKE KMIHENLRGI HENETDSWTV
   541  MQINKNSTSG TIKETDDIDD IFALMGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEPRO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 18 nTPM
  • lymph node: 12 nTPM
  • retina: 11 nTPM
  • thyroid gland: 11 nTPM
  • testis: 11 nTPM
  • skin: 10 nTPM

Single-cell type

  • cardiomyocytes: 72 nCPM
  • oocytes: 60 nCPM
  • gastric chief cells: 55 nCPM
  • myonuclei: 48 nCPM
  • bergmann glia: 47 nCPM
  • pituicytes/fscs: 47 nCPM

Immune cell

  • NK-cell: 4.4 nTPM
  • naive CD4 T-cell: 3.2 nTPM
  • naive CD8 T-cell: 3.2 nTPM
  • memory CD4 T-cell: 2.6 nTPM
  • MAIT T-cell: 2.3 nTPM
  • gdT-cell: 2.2 nTPM

Brain region

  • white matter: 21 nTPM
  • cerebellum: 19 nTPM
  • choroid plexus: 18 nTPM
  • medulla oblongata: 17 nTPM
  • cerebral cortex: 17 nTPM
  • basal ganglia: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NEPRO.

Disease | AllUniProt

Conditions NEPRO is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
DepMap mean gene effect
-1.28
DepMap dependency class
common

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Nucleolus and neural progenitor protein-like, N-terminal domain
  • Nucleolus and neural progenitor protein
  • Nucleolus and neural progenitor protein, N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NEPRO in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEPRO as an antibody target. Whether an autoantibody or antibody against NEPRO could matter depends on whether native NEPRO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEPRO is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEPRO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NEPRO. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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