Seroatlas · Human Serome Atlas

EPB41L5

Band 4.1-like protein 5

Also known as: BE37, E41L5_HUMAN, FLJ12957, KIAA1548, LULU, LULU1, YMO1, YRT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HCM4
Gene
EPB41L5
Ensembl
ENSG00000115109
Chromosome
2
Canonical length
733 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Predicted to enable cytoskeletal protein binding activity and protein domain specific binding activity. Predicted to be involved in actomyosin structure organization. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic foregut morphogenesis; and mesoderm morphogenesis. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

733 residues, UniProt reviewed canonical sequence.

>Q9HCM4|EPB41L5
     1  MLSFFRRTLG RRSMRKHAEK ERLREAQRAA THIPAAGDSK SIITCRVSLL DGTDVSVDLP
    61  KKAKGQELFD QIMYHLDLIE SDYFGLRFMD SAQVAHWLDG TKSIKKQVKI GSPYCLHLRV
   121  KFYSSEPNNL REELTRYLFV LQLKQDILSG KLDCPFDTAV QLAAYNLQAE LGDYDLAEHS
   181  PELVSEFRFV PIQTEEMELA IFEKWKEYRG QTPAQAETNY LNKAKWLEMY GVDMHVVKAR
   241  DGNDYSLGLT PTGVLVFEGD TKIGLFFWPK ITRLDFKKNK LTLVVVEDDD QGKEQEHTFV
   301  FRLDHPKACK HLWKCAVEHH AFFRLRGPVQ KSSHRSGFIR LGSRFRYSGK TEYQTTKTNK
   361  ARRSTSFERR PSKRYSRRTL QMKACATKPE ELSVHNNVST QSNGSQQAWG MRSALPVSPS
   421  ISSAPVPVEI ENLPQSPGTD QHDRKCIPLN IDLLNSPDLL EATIGDVIGA SDTMETSQAL
   481  NDVNVATRLP GLGEPEVEYE TLKDTSEKLK QLEMENSPLL SPRSNIDVNI NSQEEVVKLT
   541  EKCLNNVIES PGLNVMRVPP DFKSNILKAQ VEAVHKVTKE DSLLSHKNAN VQDAATNSAV
   601  LNENNVPLPK ESLETLMLIT PADSGSVLKE ATDELDALLA SLTENLIDHT VAPQVSSTSM
   661  ITPRWIVPQS GAMSNGLAGC EMLLTGKEGH GNKDGISLIS PPAPFLVDAV TSSGPILAEE
   721  AVLKQKCLLT TEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPB41L5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
53 nTPM

Expression across tissuesHPA

Tissue

  • liver: 53 nTPM
  • thyroid gland: 31 nTPM
  • kidney: 31 nTPM
  • testis: 29 nTPM
  • lung: 28 nTPM
  • retina: 26 nTPM

Single-cell type

  • podocytes: 1,344 nCPM
  • endometrial glandular cells: 362 nCPM
  • enterocytes: 349 nCPM
  • endometrial luminal cells: 343 nCPM
  • myonuclei: 321 nCPM
  • alveolar cells type 1: 318 nCPM

Immune cell

  • memory B-cell: 1.7 nTPM
  • naive B-cell: 1.3 nTPM
  • naive CD4 T-cell: 1.1 nTPM
  • naive CD8 T-cell: 0.8 nTPM
  • neutrophil: 0.7 nTPM
  • eosinophil: 0.6 nTPM

Brain region

  • cerebellum: 102 nTPM
  • thalamus: 39 nTPM
  • hypothalamus: 36 nTPM
  • midbrain: 35 nTPM
  • cerebral cortex: 34 nTPM
  • amygdala: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.02
gnomAD missense Z
0.16
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EPB41L5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPB41L5 as an antibody target. Whether an autoantibody or antibody against EPB41L5 could matter depends on whether native EPB41L5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPB41L5 is annotated at the cell surface, where native EPB41L5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EPB41L5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EPB41L5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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