Seroatlas · Human Serome Atlas

BOP1

Ribosome biogenesis protein BOP1

Also known as: BOP1_HUMAN, KIAA0124

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14137
Gene
BOP1
Ensembl
ENSG00000261236
Chromosome
8
Canonical length
746 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Enables RNA binding activity. Involved in regulation of cell cycle; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm. Part of PeBoW complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

746 residues, UniProt reviewed canonical sequence.

>Q14137|BOP1
     1  MAGSRGAGRT AAPSVRPEKR RSEPELEPEP EPEPPLLCTS PLSHSTGSDS GVSDSEESVF
    61  SGLEDSGSDS SEDDDEGDEE GEDGALDDEG HSGIKKTTEE QVQASTPCPR TEMASARIGD
   121  EYAEDSSDEE DIRNTVGNVP LEWYDDFPHV GYDLDGRRIY KPLRTRDELD QFLDKMDDPD
   181  YWRTVQDPMT GRDLRLTDEQ VALVRRLQSG QFGDVGFNPY EPAVDFFSGD VMIHPVTNRP
   241  ADKRSFIPSL VEKEKVSRMV HAIKMGWIQP RRPRDPTPSF YDLWAQEDPN AVLGRHKMHV
   301  PAPKLALPGH AESYNPPPEY LLSEEERLAW EQQEPGERKL SFLPRKFPSL RAVPAYGRFI
   361  QERFERCLDL YLCPRQRKMR VNVDPEDLIP KLPRPRDLQP FPTCQALVYR GHSDLVRCLS
   421  VSPGGQWLVS GSDDGSLRLW EVATARCVRT VPVGGVVKSV AWNPSPAVCL VAAAVEDSVL
   481  LLNPALGDRL VAGSTDQLLS AFVPPEEPPL QPARWLEASE EERQVGLRLR ICHGKPVTQV
   541  TWHGRGDYLA VVLATQGHTQ VLIHQLSRRR SQSPFRRSHG QVQRVAFHPA RPFLLVASQR
   601  SVRLYHLLRQ ELTKKLMPNC KWVSSLAVHP AGDNVICGSY DSKLVWFDLD LSTKPYRMLR
   661  HHKKALRAVA FHPRYPLFAS GSDDGSVIVC HGMVYNDLLQ NPLLVPVKVL KGHVLTRDLG
   721  VLDVIFHPTQ PWVFSSGADG TVRLFT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BOP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 69 nTPM
  • cerebellum: 35 nTPM
  • pancreas: 29 nTPM
  • esophagus: 24 nTPM
  • cerebral cortex: 23 nTPM
  • heart muscle: 22 nTPM

Single-cell type

  • esophageal basal cells: 72 nCPM
  • differentiating spermatogonia: 59 nCPM
  • undifferentiated spermatogonia: 58 nCPM
  • esophageal suprabasal cells: 52 nCPM
  • pancreatic acinar cells: 50 nCPM
  • erythrocyte progenitors: 48 nCPM

Immune cell

  • myeloid DC: 3 nTPM
  • memory B-cell: 2.6 nTPM
  • memory CD8 T-cell: 2.5 nTPM
  • intermediate monocyte: 2.3 nTPM
  • classical monocyte: 2.2 nTPM
  • memory CD4 T-cell: 2.2 nTPM

Brain region

  • cerebral cortex: 20 nTPM
  • cerebellum: 16 nTPM
  • medulla oblongata: 15 nTPM
  • hippocampal formation: 15 nTPM
  • amygdala: 14 nTPM
  • basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.32
gnomAD pLI
0.09
gnomAD missense Z
-0.26
DepMap mean gene effect
-1.21
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BOP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BOP1 as an antibody target. Whether an autoantibody or antibody against BOP1 could matter depends on whether native BOP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BOP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BOP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BOP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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