Seroatlas · Human Serome Atlas

LAS1L

Ribosomal biogenesis protein LAS1L

Also known as: FLJ12525, Las1, LAS1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y4W2
Gene
LAS1L
Ensembl
ENSG00000001497
Chromosome
X
Canonical length
734 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centriolar satellite,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Involved in rRNA processing. Located in nucleolus. Part of MLL1 complex. Implicated in Wilson-Turner syndrome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

734 residues, UniProt reviewed canonical sequence.

>Q9Y4W2|LAS1L
     1  MSWESGAGPG LGSQGMDLVW SAWYGKCVKG KGSLPLSAHG IVVAWLSRAE WDQVTVYLFC
    61  DDHKLQRYAL NRITVWRSRS GNELPLAVAS TADLIRCKLL DVTGGLGTDE LRLLYGMALV
   121  RFVNLISERK TKFAKVPLKC LAQEVNIPDW IVDLRHELTH KKMPHINDCR RGCYFVLDWL
   181  QKTYWCRQLE NSLRETWELE EFREGIEEED QEEDKNIVVD DITEQKPEPQ DDGKSTESDV
   241  KADGDSKGSE EVDSHCKKAL SHKELYERAR ELLVSYEEEQ FTVLEKFRYL PKAIKAWNNP
   301  SPRVECVLAE LKGVTCENRE AVLDAFLDDG FLVPTFEQLA ALQIEYEDGQ TEVQRGEGTD
   361  PKSHKNVDLN DVLVPKPFSQ FWQPLLRGLH SQNFTQALLE RMLSELPALG ISGIRPTYIL
   421  RWTVELIVAN TKTGRNARRF SAGQWEARRG WRLFNCSASL DWPRMVESCL GSPCWASPQL
   481  LRIIFKAMGQ GLPDEEQEKL LRICSIYTQS GENSLVQEGS EASPIGKSPY TLDSLYWSVK
   541  PASSSFGSEA KAQQQEEQGS VNDVKEEEKE EKEVLPDQVE EEEENDDQEE EEEDEDDEDD
   601  EEEDRMEVGP FSTGQESPTA ENARLLAQKR GALQGSAWQV SSEDVRWDTF PLGRMPGQTE
   661  DPAELMLENY DTMYLLDQPV LEQRLEPSTC KTDTLGLSCG VGSGNCSNSS SSNFEGLLWS
   721  QGQLHGLKTG LQLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAS1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 33 nTPM
  • cerebellum: 30 nTPM
  • midbrain: 27 nTPM
  • cerebral cortex: 25 nTPM
  • hippocampal formation: 25 nTPM
  • basal ganglia: 24 nTPM

Single-cell type

  • late spermatids: 235 nCPM
  • sertoli cells: 111 nCPM
  • epicardial cells: 86 nCPM
  • oocytes: 74 nCPM
  • erythrocyte progenitors: 58 nCPM
  • fibro-adipogenic progenitors: 55 nCPM

Immune cell

  • naive B-cell: 26 nTPM
  • myeloid DC: 24 nTPM
  • intermediate monocyte: 24 nTPM
  • memory B-cell: 24 nTPM
  • memory CD8 T-cell: 23 nTPM
  • naive CD4 T-cell: 23 nTPM

Brain region

  • spinal cord: 19 nTPM
  • basal ganglia: 17 nTPM
  • white matter: 17 nTPM
  • thalamus: 17 nTPM
  • midbrain: 16 nTPM
  • amygdala: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LAS1L.

Disease | AllUniProt

Conditions LAS1L is implicated in, by any mechanism.

  • Intellectual developmental disorder, X-linked, syndromic, Wilson-Turner type (WTS) MIM:309585

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 346 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on LAS1L was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
2.67
DepMap mean gene effect
-1.05
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Las1
  • Las1-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LAS1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAS1L as an antibody target. Whether an autoantibody or antibody against LAS1L could matter depends on whether native LAS1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAS1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LAS1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LAS1L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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