Seroatlas · Human Serome Atlas

NIPSNAP1

Protein NipSnap homolog 1

Also known as: NIPS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BPW8
Gene
NIPSNAP1
Ensembl
ENSG00000184117
Chromosome
22
Canonical length
284 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

284 residues, UniProt reviewed canonical sequence.

>Q9BPW8|NIPSNAP1
     1  MAPRLCSISV TARRLLGGPG PRAGDVASAA AARFYSKDNE GSWFRSLFVH KVDPRKDAHS
    61  TLLSKKETSN LYKIQFHNVK PEYLDAYNSL TEAVLPKLHL DEDYPCSLVG NWNTWYGEQD
   121  QAVHLWRFSG GYPALMDCMN KLKNNKEYLE FRRERSQMLL SRRNQLLLEF SFWNEPQPRM
   181  GPNIYELRTY KLKPGTMIEW GNNWARAIKY RQENQEAVGG FFSQIGELYV VHHLWAYKDL
   241  QSREETRNAA WRKRGWDENV YYTVPLVRHM ESRIMIPLKI SPLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NIPSNAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
273 nTPM

Expression across tissuesHPA

Tissue

  • liver: 273 nTPM
  • kidney: 110 nTPM
  • choroid plexus: 65 nTPM
  • parathyroid gland: 64 nTPM
  • duodenum: 63 nTPM
  • cerebral cortex: 53 nTPM

Single-cell type

  • proximal tubule cells: 50 nCPM
  • hepatocytes: 45 nCPM
  • rod photoreceptor cells: 28 nCPM
  • choroid plexus epithelial cells: 28 nCPM
  • retinal ganglion cells: 27 nCPM
  • retinal horizontal cells: 26 nCPM

Immune cell

  • T-reg: 45 nTPM
  • MAIT T-cell: 41 nTPM
  • naive CD8 T-cell: 40 nTPM
  • NK-cell: 40 nTPM
  • memory CD8 T-cell: 36 nTPM
  • memory CD4 T-cell: 35 nTPM

Brain region

  • hypothalamus: 66 nTPM
  • pons: 61 nTPM
  • cerebral cortex: 57 nTPM
  • hippocampal formation: 57 nTPM
  • basal ganglia: 56 nTPM
  • midbrain: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.1
gnomAD missense Z
1.84
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NIPSNAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NIPSNAP1 as an antibody target. Whether an autoantibody or antibody against NIPSNAP1 could matter depends on whether native NIPSNAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NIPSNAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NIPSNAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NIPSNAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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