Seroatlas · Human Serome Atlas

CIB1

Calcium and integrin-binding protein 1

Also known as: CIB, CIB1_HUMAN, KIP, SIP2-28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99828
Gene
CIB1
Ensembl
ENSG00000185043
Chromosome
15
Canonical length
191 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear bodies,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>Q99828|CIB1
     1  MGGSGSRLSK ELLAEYQDLT FLTKQEILLA HRRFCELLPQ EQRSVESSLR AQVPFEQILS
    61  LPELKANPFK ERICRVFSTS PAKDSLSFED FLDLLSVFSD TATPDIKSHY AFRIFDFDDD
   121  GTLNREDLSR LVNCLTGEGE DTRLSASEMK QLIDNILEES DIDRDGTINL SEFQHVISRS
   181  PDFASSFKIV L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
228 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 228 nTPM
  • choroid plexus: 222 nTPM
  • liver: 209 nTPM
  • kidney: 208 nTPM
  • adrenal gland: 176 nTPM
  • esophagus: 135 nTPM

Single-cell type

  • late spermatids: 2,495 nCPM
  • respiratory ciliated cells: 963 nCPM
  • fallopian tube ciliated cells: 911 nCPM
  • salivary duct cells: 645 nCPM
  • colonocytes: 615 nCPM
  • enterocytes: 594 nCPM

Immune cell

  • memory B-cell: 316 nTPM
  • total PBMC: 292 nTPM
  • naive B-cell: 281 nTPM
  • eosinophil: 197 nTPM
  • memory CD4 T-cell: 195 nTPM
  • memory CD8 T-cell: 179 nTPM

Brain region

  • choroid plexus: 63 nTPM
  • thalamus: 31 nTPM
  • spinal cord: 30 nTPM
  • hypothalamus: 29 nTPM
  • midbrain: 29 nTPM
  • medulla oblongata: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CIB1.

Disease | AllUniProt

Conditions CIB1 is implicated in, by any mechanism.

  • Epidermodysplasia verruciformis 3 (EV3) MIM:618267

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 216 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIB1 as an antibody target. Whether an autoantibody or antibody against CIB1 could matter depends on whether native CIB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIB1 is annotated at the cell surface, where native CIB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CIB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CIB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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