Seroatlas · Human Serome Atlas

NIPSNAP2

Protein NipSnap homolog 2

Also known as: GBAS, NIPS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75323
Gene
NIPSNAP2
Ensembl
ENSG00000146729
Chromosome
7
Canonical length
286 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. The encoded protein is localized to mitochondria and plays a role in oxidative phosphorylation. A pseudogene of this gene is located on the long arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

286 residues, UniProt reviewed canonical sequence.

>O75323|NIPSNAP2
     1  MAARVLRARG AAWAGGLLQR AAPCSLLPRL RTWTSSSNRS REDSWLKSLF VRKVDPRKDA
    61  HSNLLAKKET SNLYKLQFHN VKPECLEAYN KICQEVLPKI HEDKHYPCTL VGTWNTWYGE
   121  QDQAVHLWRY EGGYPALTEV MNKLRENKEF LEFRKARSDM LLSRKNQLLL EFSFWNEPVP
   181  RSGPNIYELR SYQLRPGTMI EWGNYWARAI RFRQDGNEAV GGFFSQIGQL YMVHHLWAYR
   241  DLQTREDIRN AAWHKHGWEE LVYYTVPLIQ EMESRIMIPL KTSPLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NIPSNAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
733 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 733 nTPM
  • skeletal muscle: 605 nTPM
  • heart muscle: 249 nTPM
  • thyroid gland: 81 nTPM
  • salivary gland: 75 nTPM
  • adrenal gland: 66 nTPM

Single-cell type

  • myonuclei: 406 nCPM
  • parietal cells: 389 nCPM
  • thymic myoid cells: 250 nCPM
  • fallopian tube ciliated cells: 216 nCPM
  • respiratory ciliated cells: 216 nCPM
  • choroid plexus epithelial cells: 213 nCPM

Immune cell

  • myeloid DC: 92 nTPM
  • classical monocyte: 87 nTPM
  • intermediate monocyte: 86 nTPM
  • total PBMC: 72 nTPM
  • non-classical monocyte: 69 nTPM
  • basophil: 48 nTPM

Brain region

  • choroid plexus: 44 nTPM
  • thalamus: 43 nTPM
  • hypothalamus: 41 nTPM
  • midbrain: 40 nTPM
  • spinal cord: 40 nTPM
  • basal ganglia: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NIPSNAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NIPSNAP2 as an antibody target. Whether an autoantibody or antibody against NIPSNAP2 could matter depends on whether native NIPSNAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NIPSNAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NIPSNAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NIPSNAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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