Seroatlas · Human Serome Atlas

ATG10

Ubiquitin-like-conjugating enzyme ATG10

Also known as: APG10L, ATG10_HUMAN, DKFZP586I0418, FLJ13954

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0Y0
Gene: ATG10
Ensembl: ENSG00000152348
Chromosome: 5
Canonical length: 220 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>Q9H0Y0|ATG10
     1  MEEDEFIGEK TFQRYCAEFI KHSQQIGDSW EWRPSKDCSD GYMCKIHFQI KNGSVMSHLG
    61  ASTHGQTCLP MEEAFELPLD DCEVIETAAA SEVIKYEYHV LYSCSYQVPV LYFRASFLDG
   121  RPLTLKDIWE GVHECYKMRL LQGPWDTITQ QEHPILGQPF FVLHPCKTNE FMTPVLKNSQ
   181  KINKNVNYIT SWLSIVGPVV GLNLPLSYAK ATSQDERNVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATG10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 11 nTPM
testis: 9.6 nTPM
epididymis: 7.4 nTPM
thymus: 7.2 nTPM
skeletal muscle: 6.7 nTPM
thyroid gland: 6.6 nTPM

Single-cell type

thymocytes: 432 nCPM
mesothelial cells: 315 nCPM
corticotrophs: 290 nCPM
choroid plexus epithelial cells: 260 nCPM
epicardial cells: 196 nCPM
myonuclei: 195 nCPM

Immune cell

eosinophil: 8.5 nTPM
myeloid DC: 7.5 nTPM
neutrophil: 7 nTPM
NK-cell: 6.4 nTPM
intermediate monocyte: 5.7 nTPM
plasmacytoid DC: 5.6 nTPM

Brain region

choroid plexus: 26 nTPM
cerebellum: 25 nTPM
white matter: 24 nTPM
cerebral cortex: 20 nTPM
medulla oblongata: 19 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Atg12 transferase activity
Atg12 conjugating enzyme activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATG10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATG10 as an antibody target. Whether an autoantibody or antibody against ATG10 could matter depends on whether native ATG10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATG10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATG10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...