ADRB1

Protein identityUniProt · HPA

UniProt accession

P08588

Gene

ADRB1

Ensembl

ENSG00000043591

Chromosome

10

Canonical length

477 aa

Protein class

FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Beta-1 adrenoceptors are predominately located in the heart. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Sep 2019]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>P08588|ADRB1
     1  MGAGVLVLGA SEPGNLSSAA PLPDGAATAA RLLVPASPPA SLLPPASESP EPLSQQWTAG
    61  MGLLMALIVL LIVAGNVLVI VAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVV
   121  WGRWEYGSFF CELWTSVDVL CVTASIETLC VIALDRYLAI TSPFRYQSLL TRARARGLVC
   181  TVWAISALVS FLPILMHWWR AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM
   241  AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPSPSPSPV PAPAPPPGPP RPAAAAATAP
   301  LANGRAGKRR PSRLVALREQ KALKTLGIIM GVFTLCWLPF FLANVVKAFH RELVPDRLFV
   361  FFNWLGYANS AFNPIIYCRS PDFRKAFQGL LCCARRAARR RHATHGDRPR ASGCLARPGP
   421  PPSPGAASDD DDDDVVGATP PARLLEPWAG CNGGAAADSD SSLDEPCRPG FASESKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADRB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

27 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADRB1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 74 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• SHORT SLEEP, FAMILIAL NATURAL, 2

Disease | ImmuneIEDB

Conditions an epitope on ADRB1 was assayed in.

• myocardial infarction T cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against ADRB1 are reported. Each links to that disease's full target list.

Showing 0 of 4 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for ADRB1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.54

gnomAD pLI

0

gnomAD missense Z

1.7

DepMap mean gene effect

0.12

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating adrenergic receptor signaling pathway
• adenylate cyclase-activating G protein-coupled receptor signaling pathway
• brown fat cell differentiation
• diet induced thermogenesis
• fear response
• heat generation
• negative regulation of multicellular organism growth
• norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
• positive regulation of cardiac muscle cell apoptotic process
• positive regulation of cold-induced thermogenesis
• positive regulation of heart rate by epinephrine-norepinephrine
• positive regulation of MAPK cascade
• positive regulation of the force of heart contraction by epinephrine-norepinephrine
• regulation of circadian sleep/wake cycle, sleep
• response to cold

Molecular functions

• alpha-2A adrenergic receptor binding
• beta-adrenergic receptor activity
• G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
• PDZ domain binding
• protein heterodimerization activity
• beta1-adrenergic receptor activity

Cellular components

• early endosome
• neuronal dense core vesicle
• plasma membrane
• Schaffer collateral - CA1 synapse

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• Adrenoceptor family
• GPCR, rhodopsin-like, 7TM
• 7 transmembrane receptor (rhodopsin family)
• Beta 1 adrenoceptor

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Lipoprotein
• Membrane
• Palmitate
• Phosphoprotein
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ADRB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAGI3
• GOPC
• RAPGEF2