SSNA1

Protein identityUniProt · HPA

UniProt accession

O43805

Gene

SSNA1

Ensembl

ENSG00000176101

Chromosome

9

Canonical length

119 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles,Basal body,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity and microtubule binding activity. Involved in axonogenesis; cell division; and microtubule nucleation. Located in several cellular components, including axoneme; microtubule organizing center; and midbody. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>O43805|SSNA1
     1  MTQQGAALQN YNNELVKCIE ELCQKREELC RQIQEEEDEK QRLQNEVRQL TEKLARVNEN
    61  LARKIASRNE FDRTIAETEA AYLKILESSQ TLLSVLKREA GNLTKATAPD QKSSGGRDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSNA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

123 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for SSNA1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.83

gnomAD pLI

0

gnomAD missense Z

-0.6

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axon extension
• axonogenesis
• cell division
• intraciliary transport
• microtubule cytoskeleton organization
• microtubule nucleation
• receptor clustering
• smoothened signaling pathway
• axon arborization

Molecular functions

• identical protein binding
• microtubule binding

Cellular components

• axon
• axoneme
• centriole
• centrosome
• ciliary basal body
• cytosol
• midbody
• nucleus
• plasma membrane
• supramolecular fiber

Protein domainsUniProt · Pfam · InterPro

• SSNA1 family

KeywordsUniProt

• Acetylation
• Cell cycle
• Cell division
• Cell projection
• Cilium
• Coiled coil
• Cytoplasm
• Cytoskeleton
• Flagellum
• Neurogenesis
• Nucleus

InteractionsUniProt · HPA

Protein binding partners of SSNA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SPAST
• GOPC
• LCA5
• PSMC5