Seroatlas · Human Serome Atlas

NLGN1

Neuroligin-1

Also known as: KIAA1070, NLGN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N2Q7
Gene
NLGN1
Ensembl
ENSG00000169760
Chromosome
3
Canonical length
863 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nuclear bodies,Plasma membrane
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

863 residues, UniProt reviewed canonical sequence.

>Q8N2Q7|NLGN1
     1  MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD VDPLVATNFG
    61  KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP PSPWSDIRNA TQFAPVCPQN
   121  IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS EDCLYLNIYV PTEDVKRISK ECARKPGKKI
   181  CRKGGPLTKK QTDDLGDNDG AEDEDIRDSG GPKPVMVYIH GGSYMEGTGN LYDGSVLASY
   241  GNVIVITVNY RLGVLGFLST GDQAAKGNYG LLDLIQALRW TSENIGFFGG DPLRITVFGS
   301  GAGGSCVNLL TLSHYSEGNR WSNSTKGLFQ RAIAQSGTAL SSWAVSFQPA KYARMLATKV
   361  GCNVSDTVEL VECLQKKPYK ELVDQDIQPA RYHIAFGPVI DGDVIPDDPQ ILMEQGEFLN
   421  YDIMLGVNQG EGLKFVENIV DSDDGISASD FDFAVSNFVD NLYGYPEGKD VLRETIKFMY
   481  TDWADRHNPE TRRKTLLALF TDHQWVAPAV ATADLHSNFG SPTYFYAFYH HCQTDQVPAW
   541  ADAAHGDEVP YVLGIPMIGP TELFPCNFSK NDVMLSAVVM TYWTNFAKTG DPNQPVPQDT
   601  KFIHTKPNRF EEVAWTRYSQ KDQLYLHIGL KPRVKEHYRA NKVNLWLELV PHLHNLNDIS
   661  QYTSTTTKVP STDITFRPTR KNSVPVTSAF PTAKQDDPKQ QPSPFSVDQR DYSTELSVTI
   721  AVGASLLFLN ILAFAALYYK KDKRRHDVHR RCSPQRTTTN DLTHAQEEEI MSLQMKHTDL
   781  DHECESIHPH EVVLRTACPP DYTLAMRRSP DDVPLMTPNT ITMIPNTIPG IQPLHTFNTF
   841  TGGQNNTLPH PHPHPHSHST TRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLGN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 12 nTPM
  • retina: 10 nTPM
  • cerebellum: 4.7 nTPM
  • testis: 4.5 nTPM
  • hypothalamus: 4.3 nTPM
  • hippocampal formation: 4.2 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 5,377 nCPM
  • lactotrophs: 2,990 nCPM
  • brain excitatory neurons: 2,520 nCPM
  • oligodendrocytes: 2,350 nCPM
  • brain inhibitory neurons: 2,278 nCPM
  • choroid plexus epithelial cells: 2,268 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 83 nTPM
  • hypothalamus: 66 nTPM
  • cerebral cortex: 53 nTPM
  • amygdala: 53 nTPM
  • basal ganglia: 51 nTPM
  • hippocampal formation: 49 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NLGN1.

Disease | AllUniProt

Conditions NLGN1 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.85
gnomAD missense Z
2.22
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NLGN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NLGN1 as an antibody target. Whether an autoantibody or antibody against NLGN1 could matter depends on whether native NLGN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NLGN1 is annotated at the cell surface, where native NLGN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NLGN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NLGN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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