Seroatlas · Human Serome Atlas

CCDC62

Coiled-coil domain-containing protein 62

Also known as: CCD62_HUMAN, CT109, ERAP75, FLJ40344, TSP-NY

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P9F0
Gene: CCDC62
Ensembl: ENSG00000130783
Chromosome: 12
Canonical length: 684 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Enables nuclear estrogen receptor binding activity and transcription coactivator activity. Involved in several processes, including cellular response to estradiol stimulus; estrogen receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in acrosomal vesicle and nucleus. Implicated in spermatogenic failure 67. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

684 residues, UniProt reviewed canonical sequence.

>Q6P9F0|CCDC62
     1  MNPPAAFLAG RQNIGSEVEI STIEKQRKEL QLLIGELKDR DKELNDMVAV HQQQLLSWEE
    61  DRQKVLTLEE RCSKLEGELH KRTEIIRSLT KKVKALESNQ MECQTALQKT QLQLQEMAQK
   121  ATHSSLLSED LEARNETLSN TLVELSAQVG QLQAREQALT TMIKLKDKDI IEAVNHIADC
   181  SGKFKMLEHA LRDAKMAETC IVKEKQDYKQ KLKALKIEVN KLKEDLNEKT TENNEQREEI
   241  IRLKQEKSCL HDELLFTVER EKRKDELLNI AKSKQERTNS ELHNLRQIYV KQQSDLQFLN
   301  FNVENSQELI QMYDSKMEES KALDSSRDMC LSDLENNHPK VDIKREKNQK SLFKDQKFEA
   361  MLVQQNRSDK SSCDECKEKK QQIDTVFGEK SVITLSSIFT KDLVEKHNLP WSLGGKTQIE
   421  PENKITLCKI HTKSPKCHGT GVQNEGKQPS ETPTLSDEKQ WHDVSVYLGL TNCPSSKHPE
   481  KLDVECQDQM ERSEISCCQK NEACLGESGM CDSKCCHPSN FIIEAPGHMS DVEWMSIFKP
   541  SKMQRIVRLK SGCTCSESIC GTQHDSPASE LIAIQDSHSL GSSKSALRED ETESSSNKKN
   601  SPTSLLIYKD APAFNEKASI VLPSQDDFSP TSKLQRLLAE SRQMVTDLEL STLLPISHEN
   661  LTGSATNKSE VPEESAQKNT FVSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC62 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

testis: 66 nTPM
retina: 1.3 nTPM
cerebellum: 0.7 nTPM
skeletal muscle: 0.7 nTPM
pituitary gland: 0.6 nTPM
basal ganglia: 0.5 nTPM

Single-cell type

late primary spermatocytes: 610 nCPM
early spermatids: 203 nCPM
late spermatids: 88 nCPM
somatotrophs: 49 nCPM
thyrotrophs: 37 nCPM
early primary spermatocytes: 33 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.3 nTPM
T-reg: 0.3 nTPM
MAIT T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

white matter: 6.3 nTPM
cerebral cortex: 6.2 nTPM
hippocampal formation: 5.3 nTPM
amygdala: 5 nTPM
basal ganglia: 4.8 nTPM
pons: 4.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCDC62.

Disease | AllUniProt

Conditions CCDC62 is implicated in, by any mechanism.

Spermatogenic failure 67 (SPGF67) MIM:619803

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 115 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 67

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC62 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC62 as an antibody target. Whether an autoantibody or antibody against CCDC62 could matter depends on whether native CCDC62 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC62 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC62 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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